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  • Corine St. Gelais, Suresh de Silva, +5 authors Li Wu
  • Medicine, Biology
  • Retrovirology
  • 2012 (First Publication: 11 December 2012)
  • BackgroundSAMHD1 is an HIV-1 restriction factor in non-dividing monocytes, dendritic cells (DCs), macrophages, and resting CD4+ T-cells. Acting as a deoxynucleoside triphosphate (dNTP)Expand
  • Baek Kim, Laura Anh Nguyen, Waaqo Daddacha, Joseph A. Hollenbaugh
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2012 (First Publication: 14 May 2012)
  • Background: SAMHD1 is a host antiviral component that regulates cellular dNTP levels. Results: We report a tight kinetic interplay between SAMHD1 level and the ability of HIV-1 to replicate in MDMs.Expand
  • Mark J. Dobrzanski, Joyce B. Reome, Joseph A. Hollenbaugh, Richard W. Dutton
  • Biology, Medicine
  • The Journal of Immunology
  • 2004 (First Publication: 1 February 2004)
  • Cytolytic CD8+ effector cells fall into two subpopulations based on cytokine secretion. Type 1 CD8+ T cells (Tc1) secrete IFN-γ, whereas type 2 CD8+ T cells (Tc2) secrete IL-4 and IL-5. Both effectorExpand