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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.
Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA… Expand
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the… Expand
HDAC6 inhibition synergizes with anti-PD-L1 therapy in ARID1A-inactivated ovarian cancer.
ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in over 50% of ovarian clear cell carcinoma (OCCC), a disease… Expand
ARID1A promotes genomic stability through protecting telomere cohesion
ARID1A inactivation causes mitotic defects. Paradoxically, cancers with high ARID1A mutation rates typically lack copy number alterations (CNAs). Here, we show that ARID1A inactivation causes defects… Expand
NAMPT inhibition suppresses cancer stem-like cells associated with therapy-induced senescence in ovarian cancer.
Epithelial ovarian cancer (EOC) is the most lethal of gynecologic malignancies. The standard-of-care treatment for EOC is platinum-based chemotherapy such as cisplatin. Platinum-based chemotherapy… Expand
SH2 Containing Inositol 5-Phosphatase: A View into an Immunohomeostatic Polypeptide
SH2 containing Inositol 5-Phosphatase (SHIP-1) is a Serine/Tyrosine protein phosphatase expressed in blood cells that negatively regulates the Phosphoiniositide-3-Kinase (PI3K) pathway. SHIP-1 plays… Expand
The type I TGFß receptor ALK-1 and it’s ligands promote angiogenesis (544.2)
Control of angiogenesis is critical in diseases such as cancer, heart disease, or wound repair. Growth factors such as transforming growth factor beta (TGFs) and fibroblast growth factor 2 (FGF-2)… Expand