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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells.

• Chih-Hang Anthony Tang, Joseph A Zundell, +4 authors Chih-Chi Andrew Hu
• Cancer research
• 2016

Endoplasmic reticulum (ER) stress responses through the IRE-1/XBP-1 pathway are required for the function of STING (TMEM173), an ER-resident transmembrane protein critical for cytoplasmic DNA… (More)

NAD+ metabolism governs the proinflammatory senescence-associated secretome

• Timothy Nacarelli, Lena Lau, +14 authors Rugang Zhang
• Nature Cell Biology
• 2019

Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the… (More)

SH2 Containing Inositol 5-Phosphatase: A View into an Immunohomeostatic Polypeptide

• Sean Lastorka, Joseph A Zundell, Audrey C. Shor, Tomar Ghansah
• 2011

SH2 containing Inositol 5-Phosphatase (SHIP-1) is a Serine/Tyrosine protein phosphatase expressed in blood cells that negatively regulates the Phosphoiniositide-3-Kinase (PI3K) pathway. SHIP-1 plays… (More)

The type I TGFß receptor ALK-1 and it’s ligands promote angiogenesis (544.2)

• Iain Duffy, Joseph A Zundell, Jesse Homer Robinson, James Hawker
• 2014

Control of angiogenesis is critical in diseases such as cancer, heart disease, or wound repair. Growth factors such as transforming growth factor beta (TGFs) and fibroblast growth factor 2 (FGF-2)… (More)

HDAC6 inhibition synergizes with anti-PD-L1 therapy in ARID1A-inactivated ovarian cancer.

• Takeshi Fukumoto, Nail Fatkhutdinov, +7 authors Rugang Zhang
• Cancer research
• 2019

ARID1A, encoding a subunit of the SWI/SNF complex, is the most frequently mutated epigenetic regulator in human cancers and is mutated in over 50% of ovarian clear cell carcinoma (OCCC), a disease… (More)

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