Learn More
We present a method for analysis of noisy sampled data from a single-channel patch clamp which bypasses restoration of an idealized quantal signal. We show that, even in the absence of a specific model, the conductance levels and mean dwell times within those levels can be estimated. Estimation of the rate constants of a hypothesized kinetic scheme is more(More)
Seaweb networks use digital signal processor (DSP)-based telesonar underwater acoustic modems to interconnect fixed and mobile nodes. Backbone nodes are autonomous, stationary sensors and telesonar repeaters. Peripheral nodes include unmanned undersea vehicles (UUVs) and specialized devices such as low-frequency sonar projectors. Gateway nodes provide(More)
The technique of patch clamp recording makes possible the measurement of current flowing through a single ion channel in a cell membrane. Examination of such recordings suggests that the current is quantal in nature, alternating in a seemingly random manner between "on" and "off," but the recordings are corrupted by noise from a variety of sources. In this(More)
Identification of the minimum number of ways in which open and closed states communicate is a crucial step in defining the gating kinetics of multistate channels. We used certain correlation functions to extract information about the pathways connecting the open and closed states of the cation channel of the purified nicotinic acetylcholine receptor and of(More)
This talk traces the development of Seaweb through-water networking from 1995 to the present day. Encompassing the physical, link, network, transport, and session layers of the open-systems interconnect (ISO/OSI) stack, Seaweb technology enables undersea sensor networks, autonomous/unmanned underwater vehicle (AUV/UUV) communication & navigation, and(More)
Ion channel formation by three analogues of staphylococcal delta-toxin, an amphipathic and alpha-helical channel-forming peptide, has been evaluated by measurement of ionic currents across planar lipid bilayers. Replacement of beta-branched, hydrophobic residues by leucine and movement of a tryptophan residue from the hydrophilic to the hydrophobic face of(More)
Seaweb is an underwater acoustic wide-area network connecting autonomous, distributed nodes. This paper presents a network discovery process that enables such a field of spontaneously deployed, ad hoc nodes to auto-configure network routes. The process is initialized as nodes in the network are discovered, link distances measured, and optimal routes chosen(More)
Results are reported from field tests of networked acoustic modems used for wireless real-time delivery of oceanographic measurements from a distributed array of subsurface instruments in coastal waters. The network demonstrated consists of sensor nodes, repeater nodes, gateway nodes, and a shore-based control center. Sensors are oceanographic instruments(More)