Joseph A. Rea

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The accurate identification of prevalent vertebral fractures is important in both the clinical and research setting as they are associated with increased risk of further fracture and irreversible clinical consequences. This study reports a direct comparison of prevalent vertebral deformity identification using X-ray absorptiometry (XA) scans, acquired on a(More)
Vertebral fractures are a common and important consequence of osteoporosis and are often identified via morphometric analysis of conventional lateral spine radiographs (morphometric radiography or MRX). A new method of performing vertebral morphometry using images acquired on dual-energy X-ray absorptiometry (DXA) scanners (morphometric X-ray absorptiometry(More)
Prevalent vertebral deformities are associated with a substantially increased risk of subsequent vertebral and nonvertebral fractures. Knowledge of vertebral fracture status is an important component in the prediction of further fractures in patients with osteoporosis. This study reports a comparison of the quantitative identification of vertebral(More)
Morphometric X-ray absorptiometry (MXA) uses dual-energy X-ray absorptiometry (DXA) scanners to perform vertebral morphometric measurements of the vertebrae. In this study we evaluated the four available MXA scan modes - single-energy (SE) and dual-energy fast (F), array (A) and high definition (HD) - on a commercial bone densitometer (Hologic QDR-4500A).(More)
Morphometric techniques, which use conventional lateral spine radiographs to quantify vertebral body shape (morphometric radiography, MRX), have proved a useful tool in the identification and evaluation of osteoporotic vertebral deformities. Recently a new method of acquiring the images required for vertebral morphometry using dual-energy X-ray(More)
Vertebral fractures are one of the most common consequences of osteoporosis. They are usually diagnosed by visual interpretation of lateral radiographs of the lumbar and thoracic spine. Vertebral morphometry, based on measurements of the anterior, middle, and posterior heights of the vertebral bodies from T4 to L4, is a useful adjunct to the visual reading(More)
On radiation safety grounds there is concern about the morbidity attributable to routine radiographs of the spine for the identification of new fractures in large-scale trials of fracture prevention. However, the role of the potentially safer low-radiation-dose technique of vertebral morphometry performed by third generation dual-energy X-ray absorptiometry(More)
Vertebral morphometry, the quantification of vertebral body shape, has proved a useful tool in the identification and evaluation of osteoporotic vertebral deformities in both epidemiologic surveys and clinical trials. Although conventionally it has been performed on lateral radiographs of the thoracolumbar spine (morphometric radiography, MRX), it may now(More)
If symmetric random noise is defined by its kurtosis rather<lb>than by its distribution, it can be simulated by simple combinations of ran-<lb>dom variates X I , X,, . . . uniformly distributed on the interval (-1,l).<lb>A notable example is the mock-Gaussian variate Y = 0.9628X1 +<lb>2.4938X2X3, which appears to be the simplest generator possible(More)
Morphometric X-ray absorptiometry (MXA) has recently been developed to assess vertebral deformity status using dual energy X-ray absorptiometry (DXA) machines. In contrast to bone densitometry, a vertebral morphometry phantom is not supplied by any machine manufacturer. The aim of this study was to develop a suitable phantom to quantify the accuracy and(More)