Joseph A. Potenza

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Deoxyhpusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor using spermidine as the substrate. Subsequent hydroxylation of the deoxyhypusine residue completes hypusine formation on eIF-5A. Polyamines (putrescine, spermidine, and spermine) have been implicated in tumor growth and(More)
2,2'-Bis[2-(1-propylbenzimidazol-2-yl)]biphenyl), 4, and its bis complexes with Fe(II) and Mn(II) have been prepared and characterized structurally and spectroscopically. Ligand 4 adopts an open, "trans" conformation in the solid state with the benzimidazole (BzIm) groups on opposite sides of the biphenyl unit. In its complexes with metal ions, a "cis"(More)
Novel macrocyclic bis(disulfide)tetramine ligands and several Cu(II) and Ni(II) complexes of them with additional ligands have been synthesized by the oxidative coupling of linear tetradentate N2S2 tetramines with iodine. Facile demetalation of the Ni(II) oxidation products affords the free 20-membered macrocycles meso-9 and rac-9 and the 22-membered(More)
[Zn0.99Cu0.01Cl2(C5H8N2)2], Mr = 328.43, monoclinic, P2(1)/c, a = 13.587 (1), b = 7.1324 (7), c = 16.356 (2) A, beta = 112.87 (1) degrees, V = 1460.4 (5) A3, Z = 4, Dm = 1.50 (1), Dx = 1.492 g cm-3, mu(Mo K alpha, lambda = 0.71073 A) = 20.8 cm-1, F(000) = 672.0, T = 297 (1) K, R = 0.028 for 1782 unique observed reflections. The structure contains discrete(More)
1,3,5-Tris{2'-[(pyrazol-1-yl)methyl]phenyl}benzene, 4, and its complexes with Cu(I) and Ag(I) have been prepared and characterized. Both CuI4 and AgI4 triflate crystallize in the rhombohedral space group R3, with the cations and anions each exhibiting crystallographically imposed 3-fold (C3) symmetry. In both complexes, 4 behaves as a tris(pyrazolyl)(More)
[Cu(C6H18N4)(C10H10N2)](ClO4)2, (1-benzylimidazole)[N,N-bis(2-aminoethyl)-1,2-ethanediamine]copper(II) diperchlorate (1), M(r) = 566.88, monoclinic, P2(1)/c, a = 10.549 (1), b = 9.2465 (9), c = 25.256 (2) A, beta = 101.42 (1) degrees, V = 2415 (1) A3, Z = 4, Dm = 1.54 (1), Dx = 1.559 Mg m-3, lambda (Mo K alpha) = 0.71073 A, mu = 1.18 mm-1, F(000) = 1172, T(More)
The structure of the title tri-fluoro-acetic acid adduct, C17H12N2O3·C2HF3O2, contains a tri-fluoro-acetic acid mol-ecule hydrogen bonded to the imine N atom of the imidazole ring of a nearly planar four-fused-ring system (r.m.s. deviatiation = 0.013 Å). The carb-oxy-lic acid group of the triflouro-acetic acid mol-ecule is twisted with respect to the mean(More)
Bis[(1S,2S)-trans-3,3'-(1,2-cyclohexanediyldinitrilo)bis- (2-methylpropane-2-thiolato)]-1 kappa 4N1,N1',S1,S1';2 kappa 4N2,- N2',S2,S2';3 kappa 2S1,S2';4 kappa 2S1',S2;5 kappa 2S1',S2'-triiodo-3 kappa I, 4 kappa I,- 5 kappa I-tricopper(I)dinicke1(II) bis(acetonitrile) solvate, [[Ni(C14H28N2S2)]2(CuI)3]. 2CH3CN, is one of a number of possible novel(More)
[Os3(CO)11[P(C6F5)3]], Mr = 1410.87, monoclinic, P2(1)/n, a = 19.058 (1), b = 9.109 (1), c = 20.424 (2) A, beta = 105.53 (1) degree, V = 3416 (1) A3, Z = 4, Dm = 2.74 (2), Dx = 2.743 g cm-3, mu(Mo K alpha, lambda = 0.71073 A) = 113.3 cm-1, F(000) = 2560, T = 297 (1) K, RF = 0.022 for 3529 reflections. The Os atoms form an approximate isosceles triangle.(More)
2,2,6,6-Tetrakis(mesyloxymethyl)spiro[3.3]heptane (1), C15H28O12S4, Mr = 528.64, triclinic, P1, a = 10.319 (1), b = 14.233 (2), c = 8.5187 (9) A, alpha = 97.87 (1), beta = 104.08 (1), gamma = 98.86 (1) degrees, V = 1179.0 (6) A3, Z = 2, Dm = 1.46 (1), Dx = 1.489 Mg m-3, lambda(Mo K alpha) = 0.71073 A, mu = 0.44 mm-1, F(000) = 556, T = 298 (1) K, R = 0.036(More)