Joseph A. Potenza

  • Citations Per Year
Learn More
Deoxyhpusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (eIF-5A) precursor using spermidine as the substrate. Subsequent hydroxylation of the deoxyhypusine residue completes hypusine formation on eIF-5A. Polyamines (putrescine, spermidine, and spermine) have been implicated in tumor growth and(More)
2,2'-Bis[2-(1-propylbenzimidazol-2-yl)]biphenyl), 4, and its bis complexes with Fe(II) and Mn(II) have been prepared and characterized structurally and spectroscopically. Ligand 4 adopts an open, "trans" conformation in the solid state with the benzimidazole (BzIm) groups on opposite sides of the biphenyl unit. In its complexes with metal ions, a "cis"(More)
Three complexes containing Ni(II)N(amine)2S(thiolate)2 units have been prepared and characterized. Both (R,R)-N,N'-bis(1-carboxy-2-mercaptoethyl)-1,2-diaminoethane [(R,R)-1] and N,N'-bis(2-methyl-2-mercaptoprop-1-yl)-1,3-diamino-2,2-dimethylpropane (4) act as tetradentate S-N-N-S ligands to form complexes Ni((R,R)-1) and Ni4 with nearly planar cis-NiN2S2(More)
[Ni(C5H8N2)4]2+.2ClO4-, Mr = 642.14, monoclinic, P2(1)/n, a = 17.938 (2), b = 14.438 (2), c = 11.336 (2) A, beta = 93.38 (1) degrees, V = 2931 (1) A3, Z = 4, Dm = 1.44 (1), D chi = 1.455 Mg m-3, mu(Mo K alpha, lambda = 0.71073 A) = 0.90 mm-1, F(000) = 1336, T = 297 (1) K, RF = 0.061, wRF = 0.076 for 2676 reflections. [Cu(C5H8N2)4]2+.2ClO4-, Mr = 646.97,(More)
Novel macrocyclic bis(disulfide)tetramine ligands and several Cu(II) and Ni(II) complexes of them with additional ligands have been synthesized by the oxidative coupling of linear tetradentate N2S2 tetramines with iodine. Facile demetalation of the Ni(II) oxidation products affords the free 20-membered macrocycles meso-9 and rac-9 and the 22-membered(More)
N,N,N',N'-Tetramethylimidazolidinium dichloride (1-Im-1 2Cl) has been studied as a model system for cation-anion interactions in the interfacial regions of gemini micelles by X-ray crystallography, density functional theory (DFT) calculations, and infrared spectroscopy. Single crystals of 1-Im-1 2Cl contain 1-Im-1 dications, whose five-membered rings adopt(More)
trans-3,3'-(1,2-Cyclohexanediyldinitrilo)-bis(2-methylpropane++ +-2-thiolato )]zinc(II), [Zn(C14H28-N2S2)], Zn(2), Mr = 353.89, monoclinic, C2/c, a = 17.914 (4), b = 9.440 (1), c = 10.877 (2) A, beta = 110.19 (2)degrees, V = 1726 (1) A3, Z = 4, Dm = 1.35 (1), Dx = 1.360 Mg m-3, mu(Mo K alpha, lambda = 0.71073 A) = 0.17 mm-1, F(000) = 752, T = 298 (1) K, RF(More)
The title complex, [CuCl(2)(C(21)H(22)N(4)O)], contains a bis-(benzimidazole) unit with a chiral bridgehead C atom that forms part of a tetra-hydro-pyrrole ring fused to one of the benzimidazoles. The chelate angle is 90.45 (9)° and the dihedral angle between the essentially planar benzimidazole fragments is 26.68 (9)°. The Cu(II) coordination geometry lies(More)
Five distorted-octahedral complexes containing (NH3)5Ru(III)L ions, where L = 2,4-dihydroxybenzoate or a xanthine, have been studied using a combination of X-ray crystallography, solution and polarized single-crystal electronic absorption spectroscopy, and first principles electronic structure computational techniques. Both yellow (2) and red (3) forms of(More)
2C6H6.C26H6Cl8N2O4, benzene-1,2,5,6,7,8-11,12-octachloro-N,N'-dimethylperylene-3 ,4:9,10-bis- (dicarboximide) (Cl8DMP) (2/1), Mr = 850.20, orthorhombic, Pna2(1), a = 23.076 (2), b = 7.2492 (6), c = 20.277 (2) A, V = 3392.0 (8) A3, Z = 4, Dm = 1.69 (1), Dx = 1.665 g cm-3, mu (Mo K alpha, lambda = 0.71073 A) = 7.1 cm-1, F(000) = 1712, T = 297 (1) K, RF =(More)