Cyclin-dependent kinase 5 (Cdk5) and its regulatory subunit p35 are integral players in the proper development of the mammalian central nervous system. Proteolytic cleavage of p35 generates p25, leading to aberrant Cdk5 activation. The accumulation of p25 is implicated in several neurodegenerative diseases. In primary neurons, p25 causes apoptosis and tau… (More)
A critical assumption in the rationale for the clinical application of voluntary control over central nervous system (CNS) activity is that there exists a direct relationship between specific CNS activities and specific subjective mood states. The experiment reported here was based on the idea that a joint manipulation of both cognitive and physiological… (More)
participants in the Democracy Collaborative's " State of Democratic Practice " conference, and two anonymous reviewers for generous comments on previous drafts of this article.
BACKGROUND International comparisons of dietary intake are an important source of information to better understand food habits and their relationship to nutrition related diseases. The objective of this study is to compare food intake of Brazilian adults with American adults identifying possible dietary factors associated with the increase in obesity in… (More)
This report presents national estimates of usual nutrient intake distributions from food for 24 nutrients and dietary components and compares those estimates to the Dietary Reference Intakes published by the Institute of Medicine. Data are based on 8,940 individuals ages 1 year and older (excluding breast-fed children and pregnant or lactating females) who… (More)