Joseph A Crifasi

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Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 micrograms/mL venlafaxine and 5.03 micrograms/mL(More)
A sensitive method for the quantitation of fluoxetine and norfluoxetine in biological samples was developed. Blood, urine, and tissue samples were alkalinized and extracted with N-butyl chloride. The extracts were derivatized with pentafluoropropionic anhydride before gas chromatography-mass spectrometry (GC-MS). Selected ions were monitored at m/z 117 and(More)
Basic drugs were routinely extracted from whole blood under alkaline conditions into n-butyl acetate. An aliquot of the n-butyl acetate was injected into a gas chromatograph equipped with a nitrogen-phosphorous detector and a wide-bore cross-linked 50% phenylmethyl silicone capillary column. Absolute and relative retention times were recorded for more than(More)
Guaifenesin is an over-the-counter expectorant used for chest congestion and is available both in single-ingredient formulations and in combination with antihistamines, cough suppressants and decongestants. The documented side-effects of guaifenesin are generally mild. We present the case of a 23-year-old female who committed suicide by ingestion of(More)
A simple, rapid ethanol screen based on a microdiffusion technique (Toxi-Lab alcohol test) was evaluated using whole blood and urine samples and compared to a direct injection gas chromatographic technique. A total of 204 samples were analyzed, 124 whole blood specimens and 80 urine samples. The whole blood samples showed agreement in 79 of 80 samples that(More)
Specimens that tested positive for amphetamines by immunoassay were confirmed by mass spectrometry. The absence of detectable d-amphetamine (limit of detection at 50 ng/mL) with a positive methamphetamine prompted further testing by chiral derivatization. This data demonstrates that d-amphetamine need not be present in methamphetamine positive cases.
Drug concentration is a factor in the determination of the manner of death, but considerable overlap exists between therapeutic and toxic concentrations. This study aims to quantify opioid mortality in Kansas from use of fentanyl, methadone and oxycodone and to evaluate utility of drug concentrations for the determination of the manner of death. Cases(More)
We present the first reported fatality from argon gas emboli during prostate cryosurgery. The decedent underwent cryotherapy for prostate carcinoma using cryoablation probes which were cooled with argon and nitrous oxide and warmed with helium. Minutes into the procedure he experienced sudden cardiovascular collapse and could not be resuscitated. Postmortem(More)
A fatal overdose involving tranylcypromine (Parnate) where blood, urine and tissues were quantitated using a pentafluoroproprionic anhydride (PFPA) derivative and gas-chromatography/mass spectroscopy (GCMS). The samples were re-quantified over several weeks demonstrating a significant loss of drug in tissues but not blood or urine specimens. The urine was(More)