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A species-wide phylogeographical study of the root vole (Microtus oeconomus) was performed using the whole 1140 base pair mitochondrial (mt) cytochrome b gene. We examined 83 specimens from 52 localities resulting in 65 unique haplotypes. Our results demonstrate that the root vole is divided into four main mtDNA phylogenetic lineages that seem to have(More)
Epileptic encephalopathies are a devastating group of epilepsies with poor prognosis, of which the majority are of unknown etiology. We perform targeted massively parallel resequencing of 19 known and 46 candidate genes for epileptic encephalopathy in 500 affected individuals (cases) to identify new genes involved and to investigate the phenotypic spectrum(More)
Evolutionary relationships of red-backed voles and their relatives were examined and used to test biogeographic hypotheses. Sequences of the mitochondrial cytochrome b gene were obtained for 25 individuals representing Alticola macrotis, Clethrionomys californicus, C. gapperi, C. glareolus, C. rutilus, and C. rufocanus. These were combined with 21 partial(More)
The North Pacific Coast (NPC) of North America is a region of high mammalian endemism, possibly due to its highly fragmented landscape and complex glacial history. For example, four island and one mainland subspecies of ermine, Mustela erminea, have been described as endemic to southeast Alaska alone. To better understand the role of past climatic change in(More)
The Arctic is one of the best examples of a long-term natural experiment related to the effects of global temperature change in structuring biodiversity (ACIA, 2004). Dramatic fluctuations in climate during the Pleistocene led to large ice sheets covering considerable expanses of the Arctic during glacial maxima (Andersen & Borns, 1994) and affecting(More)
Beringia is considered as an important glacial refugium that served as the main source for colonization of formerly glaciated Arctic regions. To obtain high resolution views of Arctic refugial history, we examined mitochondrial cytochrome b phylogeography in the northern genus of rodents, Lemmus (true lemmings), sampled across its circumpolar distribution.(More)
A limited search for hantaviruses in lung and liver tissues of Sorex shrews (family Soricidae, subfamily Soricinae) revealed phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) from Minnesota and in the dusky shrew (Sorex monticolus) from New Mexico and Colorado. The discovery of these shrew-borne hantaviruses, named Ash River virus(More)
Anthropogenic impacts such as habitat conversion and fragmentation, in combination with predator control and fur trapping, are responsible for substantial reductions in the ranges of many carnivores worldwide. The wolverine (Gulo gulo) is classified as vulnerable throughout the Holarctic Region by the International Union for Conservation of Nature and(More)
Jackrabbits and hares, members of the genus Lepus, comprise over half of the species within the family Leporidae (Lagomorpha). Despite their ecological importance, potential economic impact, and worldwide distribution, the evolution of hares and jackrabbits has been poorly studied. We provide an initial phylogenetic framework for jackrabbits and hares so(More)
A thirty-six year old male with a sixteen month history of a progressive neurological disorder had Behcet's disease. His initial electroencephalogram showed periodic lateralizing epileptiform discharges (PLEDs). The electroencephalographic changes in this disorder have not been described in detail in the American literature. The review of world publications(More)