Josefine Grups

  • Citations Per Year
Learn More
To evaluate the accuracy of transrectal ultrasonography in staging and detection of prostatic cancer, a prospective study was initiated. In 466 patients transrectal ultrasonography was performed before transurethral resection, suprapubic adenomectomy, or radical prostatectomy. The findings were compared with the histopathologic results. In 160 of the 466(More)
From 1982 to 1985, 225 patients with renal cell carcinoma were treated by nephrectomy. To evaluate the diagnostic significance of ultrasonography in predicting tumor stage the results of ultrasonography, computerized tomography, renal angiography and excretory urography were compared to the histopathological findings. Since local tumor extension has a(More)
Eight patients with superficial bladder cancer were treated by systemic interferon (IFN) alpha-2 application to investigate whether the rate of local tumor recurrence could be diminished. All patients had recurrent high-grade urothelial cancer. Recombinant human IFN alpha-2 was administered by daily intramuscular injections for a period of 6 weeks. The(More)
Natural killer (NK) cell stimulation can be repeatedly elicited by cyclic administration of recombinant human interferon (rHu IFN) gamma in patients with metastatic renal cell cancer. In all cycles of treatment, the elevation of the cytolytic activity of the NK cells was statistically significant. The shift of the T4/T8 ratio (T-helper/T-suppressor(More)
The treatment of metastatic renal carcinoma is still unsatisfactory because of the lack of effective systemic therapy. In 14 patients with metastatic renal carcinoma an attempt was made to influence the course of the disease by administration of recombinant human interferon (rHu-IFN) gamma; 9 patients were evaluated after treatment. There was partial(More)
In order to evaluate the antiproliferative effects of recombinant human interferon-gamma 2c (rHu IFN-gamma 2c), recombinant human interferon-gamma (rHu IFN-gamma), natural interferon-beta (IFN-beta), and their combination with cytotoxic agents, 17 different human bladder carcinoma cell lines were tested in vitro. The antiproliferative effects were compared(More)
In previous investigations [3], it was demonstrated that interferons (IFN) have antiproliferative effects in human urothelial carcinomas. However, appreciable differences were found in the sensitivity of the individual tumors investigated. We therefore examined whether this might be due to a different receptor status of the cells. The IFN-sensitive cell(More)
In order to evaluate whether the 2,5-oligo-A synthetase (OAS) is a reliable marker for monitoring a systemic interferon treatment 7 patients suffering from recurrent superficial carcinoma of the bladder and 4 patients with metastatic renal cell carcinoma were monitored during systemic interferon (IFN) treatment. Throughout the study, human recombinant IFN(More)
6 patients with recurrent high grade superficial bladder cancer were treated with human recombinant alpha-2-Interferon (alpha 2-IFN). After initial transurethral electroresection of macroscopically visible tumor, human recombinant alpha 2-IFN was administered by daily intramuscular injections for a period of 6 weeks. The influence of IFN on the patients'(More)
Interferons (IFN) are a class of glycoproteins which have antiviral, antiproliferative and immunomodulating properties. Three major classes of IFN are characterized today on the basis of antigenic and physical-chemical properties. They modulate various immunological functions and can be characterized as biological response modifiers. In addition, they have(More)