Josefine Åhsberg

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To investigate how transcription factor levels impact B-lymphocyte development, we generated mice carrying transheterozygous mutations in the Pax5 and Ebf1 genes. Whereas combined reduction of Pax5 and Ebf1 had minimal impact on the development of the earliest CD19(+) progenitors, these cells displayed an increased T cell potential in vivo and in vitro. The(More)
Published articles have been reprinted with the permission of the copyright holder. During the course of the research underlying this thesis, Amanda Nordigården was enrolled in Forum Scientium, a multidisciplinary doctoral programme at Linköping University. Printed by LiU-­‐Tryck Linköping, Sweden, 2013 iii Who's to say What's impossible Well they forgot(More)
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