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Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel
Potassium Permeation Two–pore domain potassium (K2P) channels conduct K+ ions across the plasma membrane of eukaryotic cells. They help to maintain the cellular resting potential and their modulationExpand
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Cryo-EM structure of the insect olfactory receptor Orco
The olfactory system must recognize and discriminate amongst an enormous variety of chemicals in the environment. To contend with such diversity, insects have evolved a family of odorant-gated ionExpand
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Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels
Living cells respond to mechanical forces applied to their outer membrane through processes referred to as “mechanosensation”. Faced with hypotonic shock, to circumvent cell lysis, bacteria openExpand
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A ruthenium-rhodamine complex as an activatable fluorescent probe.
We describe the synthesis and characterization of a ruthenium-bipyridyl complex bearing a rhodamine-based fluorescent ligand. The complex is weakly fluorescent due to the quenching of rhodamine. UponExpand
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Studying Mechanosensitivity of Two-Pore Domain K+ Channels in Cellular and Reconstituted Proteoliposome Membranes.
Mechanical force sensation is fundamental to a wide breadth of biology from the classic senses of touch, pain, hearing, and balance to less conspicuous sensations of proprioception, blood pressure,Expand
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Microbes modulate sympathetic neurons via a gut-brain circuit
Gut-brain connections monitor the intestinal tissue and its microbial and dietary content1, regulating both intestinal physiological functions such as nutrient absorption and motility2-4, andExpand
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