Josefina Guerrero García

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Dengue virus infections are a major cause of morbidity in tropical countries. Early detection of dengue hemorrhagic fever (DHF) may help identify individuals that would benefit from intensive therapy. Predictive modeling was performed using 11 laboratory values of 51 individuals (38 DF and 13 DHF) obtained on initial presentation using logistic regression.(More)
This paper addresses the need for supporting the design of user interfaces for workflow management systems. Based on the already existing task and domain models, an approach is proposed to design a workflow model that explicitly articulates its new concepts with respect to the concepts belonging to the task and the domain, but with some extensions. The(More)
BACKGROUND Limited information exists on the epidemiology of acute febrile respiratory illnesses in tropical South American countries such as Venezuela. The objective of the present study was to examine the epidemiology of influenza-like illness (ILI) in two hospitals in Maracay, Venezuela. METHODOLOGY/PRINCIPAL FINDINGS We performed a prospective(More)
BACKGROUND Tropical countries are thought to play an important role in the global behavior of respiratory infections such as influenza. The tropical country of Ecuador has almost no documentation of the causes of acute respiratory infections. The objectives of this study were to identify the viral agents associated with influenza like illness (ILI) in(More)
During the stage of system requirements gathering, model elicitation is aimed at identifying in textual scenarios model elements that are relevant for building a first version of models that will be further exploited in a model-driven engineering method. When multiple elements should be identified from multiple interrelated conceptual models, the complexity(More)
BACKGROUND Despite the disease burden imposed by respiratory diseases on children in Central America, there is a paucity of data describing the etiologic agents of the disease. AIMS To analyze viral etiologic agents associated with influenza-like illness (ILI) in participants reporting to one outpatient health center, one pediatric hospital, and three(More)
The human metapneumovirus (HMPV) is responsible for acute respiratory tract infections in young children, elderly patients, and immunocompromised hosts. In this study, we genetically analyzed the circulating HMPV in Central and South America from July 2008 to June 2009 and characterized the strains present in this region. Samples were collected during an(More)
IEX-1 is an early response and NF-kappaB target gene implicated in the regulation of cellular viability. We show here that IEX-1 is a substrate for ERKs and that IEX-1 and ERK regulate each other's activities. IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation. IEX-1 interacts(More)
A user interface description language (UIDL) consists of a specification language that describes various aspects of a user interface under development. A comparative review of some selected user interface description languages is produced in order to analyze how they support the various stages of user interface development life cycle and development goals,(More)
BACKGROUND Dengue virus (DENV) infection can range in severity from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Changes in host gene expression, temporally through the progression of DENV infection, especially during the early days, remains poorly characterized. Early diagnostic markers for DHF are also(More)