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IEX-1 is an early response and NF-kappaB target gene implicated in the regulation of cellular viability. We show here that IEX-1 is a substrate for ERKs and that IEX-1 and ERK regulate each other's activities. IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation. IEX-1 interacts(More)
This paper addresses the need for supporting the design of user interfaces for workflow management systems. Based on the already existing task and domain models, an approach is proposed to design a workflow model that explicitly articulates its new concepts with respect to the concepts belonging to the task and the domain, but with some extensions. The(More)
During the stage of system requirements gathering, model elicitation is aimed at identifying in textual scenarios model elements that are relevant for building a first version of models that will be further exploited in a model-driven engineering method. When multiple elements should be identified from multiple interrelated conceptual models, the complexity(More)
Multiple myeloma (MM) remains incurable partly because no effective cell cycle-based therapy has been available to both control tumor cell proliferation and synergize with cytotoxic killing. PD 0332991 is an orally active small molecule that potently and specifically inhibits Cdk4 and Cdk6. It has been shown to induce rapid G(1) cell cycle arrest in primary(More)
A user interface description language (UIDL) consists of a specification language that describes various aspects of a user interface under development. A comparative review of some selected user interface description languages is produced in order to analyze how they support the various stages of user interface development life cycle and development goals,(More)
Thrombopoietin (TPO) regulates growth and differentiation of megakaryocytes. We previously showed that extracellular signal-regulated kinases (ERKs) are required for TPO-mediated full megakaryocytic maturation in both normal progenitors and a megakaryoblastic cell line (UT7) expressing the TPO receptor (Mpl). In these cells, intensity and duration of(More)
Inhibition of Cdk4/Cdk6 by p18(INK4c) (p18) is pivotal for generation of noncycling immunoglobulin (Ig)-secreting plasma cells (PCs). In the absence of p18, CD138(+) plasmacytoid cells continue to cycle and turnover rapidly, suggesting that p18 controls PC homeostasis. We now show that p18 selectively acts in a rare population of rapidly cycling(More)
OBJECTIVE Increasing evidence suggests that nitric oxide participates in the pathophysiology of intestinal barrier function/dysfunction and inflammation. Increases in inducible nitric oxide synthase (iNOS) mRNA and protein expression have been observed in colonic mucosal biopsies of adults with inflammatory bowel disease (IBD). It is unclear whether iNOS(More)
This paper addresses the need for designing user interfaces (UIs) to workflow information systems by adopting a model-centric approach. We introduce a conceptual workflow model to determine system func-tionalities of workflow. The model is exploited in order to systematically derive UIs to access these functional-ities. The workflow model is recursively(More)