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Anesthetics can either promote or inhibit the development of neurogenic pulmonary edema (NPE) after central nervous system (CNS) injury. The influence of isoflurane was examined in male Wistar rats using 1.5%, 2%, 2.5%, 3%, 4%, or 5% isoflurane in air. Epidural balloon compression of the thoracic spinal cord was performed. The development of NPE was(More)
Calcium sensitization mediated by RhoA/Rho kinase pathway can be evaluated either in the absence (basal calcium sensitization) or in the presence of endogenous vasoconstrictor systems (activated calcium sensitization). Our aim was to compare basal and activated calcium sensitization in three forms of experimental hypertension with increased sympathetic tone(More)
Activation of nuclear factor-κB (NF-κB) by increased production of reactive oxygen species (ROS) might induce transcription and expression of different antioxidant enzymes and also of nitric oxide synthase (NOS) isoforms. Thus, we aimed at studying the effect of NF-κB inhibition, caused by JSH-23 (4-methyl-N (1)-(3-phenyl-propyl)-benzene-1,2-diamine)(More)
Neurogenic pulmonary edema (NPE) is a life-threatening complication of central nervous system (CNS) injuries. This review summarizes current knowledge about NPE etiology and pathophysiology with an emphasis on its experimental models, including our spinal cord compression model. NPE may develop as a result of activation of specific CNS trigger zones located(More)
at the age of 90 years. He became famous for his concept of critical developmental periods, suggesting that some abnormalities seen in adulthood might be the late consequences of early interventions applied in particular critical developmental periods. The primary focus of his research was the regulation of water and electrolyte metabolism in developing(More)
The activation of Ca(2+)-dependent Cl(-) channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase Ca(2+) entry. Hypertension and ageing are associated with altered Ca(2+) handling including possible activation of Ca(2+)-dependent Cl(-) channels. Our study was aimed to determine(More)
A bio-cybernetical model of blood pressure regulation in rats is presented. Time-responses of blood pressure after administration of selected drugs are identified and linear dynamic models of the cardiovascular system using genetic algorithms are calculated in the Matlab environment. The three major regulation systems – sympathetic nervous system,(More)
A mathematical model of blood pressure regulation in rats is presented. The three major regulatory systems - sympathetic nervous system, renin-angiotensin-aldosterone system and L-Arginine/nitric oxide system are considered. Time-responses of blood pressure after administration of selected drugs are identified and linear dynamic models of the cardiovascular(More)
11β-Hydroxysteroid dehydrogenase type 1 (11HSD1) is a microsomal NADPH-dependent oxidoreductase which elevates intracellular concentrations of active glucocorticoids. Data obtained from mouse strains with genetically manipulated 11HSD1 showed that local metabolism of glucocorticoids plays an important role in the development of metabolic syndrome. Tissue(More)
The transport of L-leucine across the blood-brain barrier was studied in heterozygous (NON-DI) and homozygous (DI) Brattleboro male rats using the carotid bolus injection technique. Furthermore, general hemodynamic parameters and cerebral blood flow were measured. No significant hemodynamic differences were found between DI and NON-DI rats except for a 22%(More)
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