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A group of 119 patients suffering from a severe psychiatric postpartum disorder who were admitted for the first time in their life to a psychiatric hospital has been investigated. The onset of illness occurred within 3 months following delivery. The patients represented 92% of the total sample fulfilling the inclusion criteria. A follow-up investigation was(More)
Among 30 women suffering from a postpartum psychosis without affective syndrome, and for whom this episode of illness was the first leading to psychiatric hospitalisation, 19 fulfilled in the long-term course the DSM-III-R criteria for schizophreniform psychosis (SCHF) or brief reactive psychosis (BRP), and 11 fulfilled the criteria for schizophrenia (SCH).(More)
A group of 30 patients suffering from endogenous depression was treated with 150 mg amitriptyline (AT) for 21 days. Depression ratings and determinations of total and free plasma AT and nortriptyline (NT) were performed weekly. No correlation between clinical improvement and any of the biochemical parameters was found. Thus, this study does not support the(More)
The EPs to bilaterally presented non-verbal and non-cognitive visual and auditory stimuli were studied in 15 schizophrenics and 15 normal subjects. Many anomalies of exogenous components of VEPs and AEPs were observed in schizophrenics in comparison with control subjects, pointing to an abnormal cerebral functioning. So, the patients presented: (1) a less(More)
Alpha 1-acid glycoprotein (AAG) is one of the plasma proteins that bind basic drugs, like amitriptyline (AT) and its metabolite nortriptyline (NT). Two types of genetic polymorphism have been described for AAG: polymorphic forms which, on electrophoresis of the native protein, give four patterns with 5, 6, 7 or 8 bands, and the variants which on by(More)
A group of 57 women, who had been hospitalised for puerperal psychiatric disorders from 1958 to 1977, were reexamined in 1982. The aim of the study was to determine the proportion of patients who had suffered from nonpuerperal psychotic relapses or other subsequent psychopathology, to define the sample diagnostically, taking into account progress in(More)
Ten healthy volunteers were injected i.v. with 5 mg Ro 15-1788, a specific benzodiazepine antagonist, or placebo in a double-blind randomised design. In the EEG, Ro 15-1788 led--with some topographical variations--to a diminution of theta and alpha power, an increase of alpha mean frequency and a decrease of delta mean frequency. In auditory evoked(More)
A group of 80 women suffering from a severe psychiatric post-partum disorder and hospitalized for the first time in their lives was followed up between 4 and 35 years later. Besides the further evolution of psychic health of the patients, the occurrence of endogenous (i.e., functional) psychoses in first degree relatives was investigated. A global morbidity(More)
As part of a follow-up and family study of postpartum psychoses, this episode of illness being the first leading to psychiatric hospitalisation, patients with puerperal episodes (PE) and nonpuerperal episodes (NPE) of illness in the long-term course (n = 79) were compared to patients with PE only (n = 40). Few differences were found. Relatives of patients(More)
The therapeutic efficacy of lithium added to tricyclic antidepressants (TCA) or related thymoleptics was investigated in 27 endogenous depressive patients responding unsatisfactorily to these drugs alone. All patients received lithium during two weeks, however, with a delay of one week in 13 of them, the attribution to active treatment or placebo for the(More)