Josef Guttmann

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BACKGROUND Intratracheal pressure (Ptrach) should be the basis for analysis of lung mechanics. If measured at all, Ptrach is usually assessed by introducing a catheter into the trachea via the lumen of the endotracheal tube (ETT). The authors propose a computer-assisted method for calculating Ptrach on a point-by-point basis by subtracting the(More)
The considerable additional ventilatory work needed to overcome the resistance of the endotracheal tube (ETT) is flow-dependent. In spontaneously breathing intubated patients this additional ventilatory work is therefore dependent on the flow pattern and cannot be adequately compensated for by support with a constant pressure. We propose a method to fully(More)
Since the adult respiratory distress syndrome (ARDS) lung is known to be inhomogeneous, one could expect an uneven distribution of expiratory time constant during uninterrupted mechanical ventilation. We investigated the time constant/volume relationship of passive expiration, and their modification by external resistive elements. In 12 paralysed intubated(More)
Objective: Adaptation of ventilator settings to the individual's respiratory system mechanics requires information about the pressure-volume relationship and the change of compliance which is dependent on inflated volume. Unfortunately, established methods of obtaining this information are invasive and time-consuming, and, therefore, not well suited for(More)
Pharmacokinetic parameters of amoxicillin were studied in healthy fasted subjects afqer both oral and intravenous administration of a single 500-mg dose. Serum levels and urinary excretion rates were determined at various time intervals by a microbiological method. The conventional two-compartment model with elimination occurring from the central(More)
In a physical model of a pediatric respiratory system we measured the pressure drop across ETTs of 3 and 4mm inner diameter (ID) when we varied frequency, mean airway pressure and pressure amplitude of high-frequency-oscillation-ventilation (HFOV). Depending on ventilator settings the relative loss of mean pressure amplitude caused by the ETT ranged from(More)
BACKGROUND Automatic tube compensation (ATC) is a new option to compensate for the pressure drop across the endotracheal or tracheostomy tube (ETT), especially during ventilator-assisted spontaneous breathing. While several benefits of this mode have so far been documented, ATC has not yet been used to predict whether the ETT could be safely removed at the(More)
At present, most methods of lung mechanics analysis do not take nonlinearities of compliance and resistance into account. Nevertheless, nonlinearity of compliance is an inherent property of the respiratory system in ARDS and nonlinearity of resistance is an inherent property of the endotracheal tube. Herein we describe a computer-assisted multipoint method(More)
Under mechanical volume-controlled ventilation, the intensive care patient can develop intrinsic positive end-expiratory pressure (iPEEP); that is, the passive expiration is terminated by the following inspiration before the alveolar pressure comes to its physical equilibrium value. We present a mathematical method to estimate this alveolar dynamic iPEEP(More)
Detecting and differentiating central and obstructive respiratory events is an important aspect of the diagnosis of sleep-related breathing disorders with respect to the choice of an appropriate treatment. The purpose of this study was to evaluate the performance of a new algorithm for automated detection and classification of apneas and hypopneas, compared(More)