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Animal models are widely used to study alterations caused by Parkinson's disease (PD). However, in general, pharmacological models do not express the progressive nature of the disease, being characterized by immediate severe motor impairment after a single dose of the drug. Reserpine administration in rodents has been suggested as a pharmacological model of(More)
The administration of reserpine to rodents was one of the first models used to investigate the pathophysiology and screening for potential treatments of Parkinson's disease (PD). The reserpine model was critical to the understanding of the role of monoamine system in the regulation of motor and affective disorders, as well as the efficacy of current PD(More)
Studies have suggested that cognitive deficits can precede motor alterations in Parkinson's disease (PD). However, in general, classic animal models are based on severe motor impairment after one single administration of neurotoxins, and thereby do not express the progressive nature of the pathology. A previous study showed that the repeated administration(More)
Episodic memory reflects the capacity to recollect what, where, and when a specific event happened in an integrative manner. Animal studies have suggested that the medial temporal lobe and the medial pre-frontal cortex are important for episodic-like memory (ELM) formation. The goal of present study was to evaluate whether there are different patterns of(More)
Multielectrodes have been used with great success to simultaneously record the activity of neuronal populations in awake, behaving animals. In particular, there is great promise in the use of this technique to allow the control of neuroprosthetic devices by human patients. However, it is crucial to fully characterize the tissue response to the chronic(More)
A commentary on Basal ganglia circuits underlying the pathophysiology of levodopa-induced dyskinesia by Barroso-Chinea, P., and Bezard, E. Among the neurodegenerative movement disorders, Parkinson's disease (PD) is the most prevalent (Schapira, 2009), affecting about 1% of people aged over 55 years, with a increase of fivefold by the age of 70,(More)
The term dementia derives from the Latin demens (" de " : private, " mens " : mind, intelligence , judgment— " without a mind "). The American Psychiatric Association (APA) describes it as " any mental impairment , or global cognitive decline in a previously unimpaired person " and is characterized by a deterioration of cog-nitive, intellectual, emotional,(More)
Recovering of people suffering from spinal cord and brain lesion is a medical challenge. Brain-machine interface (BMI) emerges as a potential candidate, by allowing patients to use their own brain activity to reestablish sensorimotor control of paralyzed body parts. BMI can be divided in two main groups: non-invasive, based in the capture of the neuronal(More)
Epilepsy affects at least 50 million people worldwide, and the available treatment is associated with various side effects. Approximately 20–30% of the patients develop seizures that persist despite careful monitored treatment with antiepileptic drugs. Thus, there is a clear need for the development of new antiepileptic drugs, and the venoms can be an(More)