Jose Roberto Fernandez

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α-Synuclein (α-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark features of Parkinson's disease (PD) and other neurodegenerative disorders. Phosphorylation of this protein at serine 129 is believed to promote its aggregation and neurotoxicity, suggesting that this post-translational modification could be a(More)
Consumption of coffee is associated with reduced risk of Parkinson’s disease (PD), an effect that has largely been attributed to caffeine. However, coffee contains numerous components that may also be neuroprotective. One of these compounds is eicosanoyl-5-hydroxytryptamide (EHT), which ameliorates the phenotype of α-synuclein transgenic mice associated(More)
As network capacities increase, wide-area distributed parallel computing may become feasible. This paper addresses one of the issues involved in using an asynchronous transfer mode (ATM) network for such a purpose ¿ that of developing an appropriate call admission control (CAC) procedure for such applications given the special nature of their traffic. In(More)
A minor component of coffee unrelated to caffeine, eicosanoyl-5-hydroxytryptamide (EHT), provides protection in a rat model for Alzheimer's disease (AD). In this model, viral expression of the phosphoprotein phosphatase 2A (PP2A) endogenous inhibitor, the I2(PP2A), or SET protein in the brains of rats leads to several characteristic features of AD including(More)
—The clustering or partitioning of a dataset's records into groups of similar records is an important aspect of knowledge discovery from datasets. A considerable amount of research has been applied to the identification of clusters in very large multi-dimensional and static datasets. However, the traditional clustering and/or pattern recognition algorithms(More)
As network capacities increase, wide-area distributed parallel computing may become feasible. This paper addresses one of the issues involved in using an asynchronous transfer mode (ATM) network for such a purpose|that of developing an appropriate call admission control (CAC) procedure for such applications given the special nature of their traac. In this(More)
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