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CD8 glycoproteins play an important role in both the maturation and function of MHC class I-restricted T lymphocytes. A 25-year-old man, from a consanguineous family, with recurrent bacterial infections and total absence of CD8(+) cells, was studied. Ab deficiencies and ZAP-70 and TAP defects were ruled out. A missense mutation (gly90-->ser) in both alleles(More)
OBJECTIVE To investigate the possible association between Fc receptor (FcR) gamma polymorphisms and systemic lupus erythematosus (SLE). METHODS We have investigated the full FcR gamma gene for polymorphisms using polymerase chain reaction (PCR)-single strand conformational polymorphism and DNA sequencing. The polymorphisms identified were genotype using(More)
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