Jose-Maria Pena

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In this paper, we present an algorithm to create 3D segmentations of neuronal cells from stacks of previously segmented 2D images. The idea behind this proposal is to provide a general method to reconstruct 3D structures from 2D stacks, regardless of how these 2D stacks have been obtained. The algorithm not only reuses the information obtained in the 2D(More)
Synaptic disruption is an early pathological sign of the neurodegeneration of Dementia of the Alzheimer's type (DAT). The changes in network synchronization are evident in patients with Mild Cognitive Impairment (MCI) at the group level, but there are very few Magnetoencephalography (MEG) studies regarding discrimination at the individual level. In an(More)
Chemical synaptic transmission involves the release of a neurotransmitter that diffuses in the extracellular space and interacts with specific receptors located on the postsynaptic membrane. Computer simulation approaches provide fundamental tools for exploring various aspects of the synaptic transmission under different conditions. In particular, Monte(More)
The design of the control mechanisms for the agents of modern video games is one of the main tasks involved in the game design process. This task grows in complexity as either the number of different game agents or the number of possible actions increase. An alternative mechanism to avoid hard-coding of agent controllers is the use of learning mechanisms to(More)
With the growing body of research on traumatic brain injury and spinal cord injury, computational neuroscience has recently focused its modeling efforts on neuronal functional deficits following mechanical loading. However, in most of these efforts, cell damage is generally only characterized by purely mechanistic criteria, functions of quantities such as(More)
The study conducted in this work analyses the interactions between different Evolutionary Algorithms when they are hybridized. For this purpose, the phylogenetic tree of the best solution reported by the hybrid algorithm is reconstructed, and the relationships among the ancestors of this solution are established. For each of these ancestors, the(More)
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