Jose-Manuel R Ferrer

Learn More
The ontogeny of dopamine terminals, mu opiate receptors and acetylcholinesterase (AChE) in rat striatum were examined during the first two weeks postnatally using fluorescence histochemistry, autoradiography and AChE stain, respectively. The most dense regions of all three markers were superimposable, particularly in the dorsal third of the striatum, as(More)
The tegument of Postorchigenes gymnesicus has been studied by scanning and transmission electron microscopy. The general body tegument is spinous and contains mitochondria, biconcave disc-shaped vesicles bounded by an unitary membrane and displaying a protein content, and scarce spherical bodies. The tegument covering specialized body regions is aspinous.(More)
Experimental adults and natural metacercariae of Brachylaima sp. (Digenea: Brachylaimidae) were processed for transmission and scanning electron microscopy, for tetramethyl rhodamine isothiocyanate phalloidin fluorescence, conventional and confocal microscopy and for monoclonal anti-actin antibody immunoelectron microscopy, to describe the ultrastructural(More)
Sections from freshly frozen neonatal rat brain, ages 0-21 days, were incubated with [3H]spiperone (SP). Initial studies characterized the binding sites for SP in terms of association and dissociation rates, saturability and pharmacology. The binding sites were found to be predominantly dopamine D2 receptors in sections centered in the striatum and these(More)
It has been described that "typical" antipsychotic drugs (APDs) induce characteristic within-session response decrements in operant behaviors, including intracranial self-stimulation (ICSS). In contrast, recent reports have shown that in food operant behavior, clozapine and a number of "atypical" APDs do not give rise to within-session effects. However, to(More)
We previously demonstrated that tolerance to carbamazepine's anticonvulsant effects occurs only with contingent presentation of the drug relative to the seizure (i.e., drug administration before but not after the seizure). Moreover, this tolerance can be reversed by altering the contingencies of drug administration (e.g., giving the drug after the seizure(More)
  • 1