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STUDY DESIGN A retrospective study of vertebral artery injury diagnosed during the last 6 years in our institution. OBJECTIVES To determine the clinical and radiologic features of vertebral artery injury. SUMMARY OF BACKGROUND DATA Extracranial occlusion of the vertebral artery associated with cervical spine fracture is uncommon and can cause serious(More)
The addition of oral capecitabine to docetaxel improves response rate, time to progression (TTP) and overall survival in anthracycline-pretreated metastatic breast cancer (MBC). This phase II study evaluates the efficacy and safety of a 21-day cycle of oral capecitabine (1000 mg m(-2) twice daily, days 1-14) plus i.v. paclitaxel (175 mg m(-2), day 1) in(More)
Several data suggest that immature lymphoid cells are more prone to penetration and therefore are affected more by antibodies than their mature counterparts. In this study, we examined the penetration of monoclonal anti-DNA antibodies in several models of immature cells. Results confirm that most anti-DNA antibodies penetrate larger proportions of immature(More)
Neurofibromatosis is an autosomal dominant genetic disease, characterized by café au lait spots, neurofibromas and several bony anomalies. Deformities of the spine are the most frequent alterations. Involvement of the cervical spine has been studied less frequently. The case of a 16-year-old male patient affected by neurofibromatosis, with cervical pain(More)
A simple procedure for the radioimmunoassay of corticosterone using tritiated corticosterone has been described for rat. The use of trypsin to hydrolyze serum proteins allowed to eliminate the extraction of the steroid from the serum. A highly significant correlation between direct and conventional (ether extraction) radioimmunoassays was found.(More)
The effect of two different population densities (3 and 9 animals/cage) on emotional reactivity, measured by their performance in an exploratory box, and pituitary-adrenal response to acute noise stress are compared. The crowded rats showed a higher defecation rate and lower exploratory activity than the control rats. Adrenocorticotropin (ACTH) response to(More)
BACKGROUND Plasma cortisol, beta-endorphin, corticotropin, corticotropin-releasing factor, and salivary cortisol concentrations, resting and after ingestion of 1 mg of dexamethasone, were investigated in depressed patients and controls. METHODS Fourteen outpatients from the psychiatric department diagnosed with depressive disorder (ICD-10 Classification)(More)
The effect on emotional reactivity produced by a model for chronic stress in which different types of acute stresses were randomly combined for 29 days was studied in adult male rats. Chronically stressed rats showed a slight decrease in body weight gain and an increase in relative adrenal weight. Chronic stress did not modify defecation rate but reduced(More)
The effect of various population densities on corticoadrenal function was studied in prepuberal male mice. High population densities decreased body weight gain. Neither adrenal weight nor basal serum corticosterone were modified by crowding. However, corticoadrenal response to some acute stresses such as noise and forced swimming was higher in crowded mice.(More)