Jose Luis Ambite

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The power of web services can only be realized when web services are utilized as building blocks to dynamically compose new web services. The Building Finder application is an example application that integrates information from several web services by modeling the web services as information sources in a mediator-based architecture. The paper also(More)
Genetic studies have identified thousands of variants associated with complex traits. However, most association studies are limited to populations of European descent and a single phenotype. The Population Architecture using Genomics and Epidemiology (PAGE) Study was initiated in 2008 by the National Human Genome Research Institute to investigate the(More)
The field of phenomics has been investigating network structure among large arrays of phenotypes, and genome-wide association studies (GWAS) have been used to investigate the relationship between genetic variation and single diseases/outcomes. A novel approach has emerged combining both the exploration of phenotypic structure and genotypic variation, known(More)
Using a phenome-wide association study (PheWAS) approach, we comprehensively tested genetic variants for association with phenotypes available for 70,061 study participants in the Population Architecture using Genomics and Epidemiology (PAGE) network. Our aim was to better characterize the genetic architecture of complex traits and identify novel(More)
The EDC project is developing new methods to make data that has been represented in disparate ways and stored in heterogeneous forms available to users in an integrated, manageable, and understandable way. Our approach is to represent the structure and types of data in the disparate collections in a standard format (called a domain model) and then to embed(More)
Despite evidence of the clustering of metabolic syndrome components, current approaches for identifying unifying genetic mechanisms typically evaluate clinical categories that do not provide adequate etiological information. Here, we used data from 19,486 European American and 6,287 African American Candidate Gene Association Resource Consortium(More)
The Metabochip is a custom genotyping array designed for replication and fine mapping of metabolic, cardiovascular, and anthropometric trait loci and includes low frequency variation content identified from the 1000 Genomes Project. It has 196,725 SNPs concentrated in 257 genomic regions. We evaluated the Metabochip in 5,863 African Americans; 89% of all(More)
Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction of association with 20 T2D risk variants generalizes across six major racial/ethnic groups in the U.S. as part of the Population Architecture using Genomics and Epidemiology Consortium (16,235(More)
Due to the recent growth of the World Wide Web, numerous spatio-temporal applications can obtain their required information from publicly available web sources. We consider those sources maintaining moving objects with prede-fined paths and schedules, and investigate different plans to perform queries on the integration of these data sources efficiently.(More)
The Internet is an extraordinary resource for information about countries throughout the world. There is detailed information about weather, geography, transportation, politics, news, etc. This data comes in a variety of forms including web pages, databases, maps, satellite imagery , newspapers, online radio and television, and so on. The problem, of(More)