Jose L. Rubio-Guivernau

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MOTIVATION Multi-view microscopy techniques such as Light-Sheet Fluorescence Microscopy (LSFM) are powerful tools for 3D + time studies of live embryos in developmental biology. The sample is imaged from several points of view, acquiring a set of 3D views that are then combined or fused in order to overcome their individual limitations. Views fusion is(More)
Laura Fernandez-de-Manuel1,5, Maria J. Ledesma-Carbayo1,5, Daniel Jimenez-Carretero1,5, Javier Pascau2, Jose L. Rubio-Guivernau1,5, Jose M. Tellado3, Enrique Ramon4, Manuel Desco2 and Andres Santos1,5 1Biomedical Image Technologies Lab, Universidad Politécnica de Madrid 2Medicina y Cirugía Experimental, Hospital General Universitario Gregorio Marañón 3(More)
Background In patients with prior myocardial infarction, intra-scar surviving fibers may create conducting channels (CC) which are the substrate of most sustained monomorphic ventricular tachycardias (VT). These channels can be identified by endocardial voltage mapping. Recent studies show high correlation between information from endocardial voltage(More)
Optical Coherence Tomography (OCT) has shown a great potential as a complementary imaging tool in the diagnosis of skin diseases. Speckle noise is the most prominent artifact present in OCT images and could limit the interpretation and detection capabilities. In this work we propose a new speckle reduction process and compare it with various denoising(More)
The reconstruction of the cell lineage tree of early zebrafish embryogenesis requires the use of in-vivo microscopy imaging and image processing strategies. Second (SHG) and third harmonic generation (THG) microscopy observations in unstained zebrafish embryos allows to detect cell divisions and cell membranes from 1-cell to 1K-cell stage. In this article,(More)
BACKGROUND/OBJECTIVE Radiofrequency (RF) catheter ablation is a minimally invasive medical procedure used to thermally destroy the focus of cardiac arrhythmias. Novel optical techniques are now being integrated into RF catheters in order to detect the changes in tissue properties. Loss of birefringence due to fiber denaturation at around 70°C is related to(More)
A novel radiofrequency ablation catheter has been developed with integrated custom designed optics, enabling real-time monitoring of radiofrequency ablation procedures through polarization-sensitive optical coherence reflectometry. The optics allow for proper tissue illumination through a view-port machined in the catheter tip, thus providing lesion depth(More)
BACKGROUND Endo-epicardial substrate ablation reduces ventricular tachycardia (VT) recurrences; however, not all patients in whom the epicardium is explored have a VT substrate. Contrast-enhanced magnetic resonance imaging (ceMRI) is used to characterize VT substrate after myocardial infarction. OBJECTIVE The purpose of this study was to determine if(More)
OBJECTIVES We performed noninvasive identification of post-infarction sustained monomorphic ventricular tachycardia (SMVT)-related slow conduction channels (CC) by contrast-enhanced magnetic resonance imaging (ceMRI). BACKGROUND Conduction channels identified by voltage mapping are the critical isthmuses of most SMVT. We hypothesized that CC are formed by(More)
Optical Coherence Tomography (OCT) has shown a great potential as a complementary imaging tool in the diagnosis of skin diseases. Speckle noise is the most prominent artifact present in OCT images and could limit the interpretation and detection capabilities. In this work we evaluate various denoising filters with high edge-preserving potential for the(More)