Jose L. Gracia

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CONTEXT A comparison of the efficacy and safety of the Laryngeal Mask Airway (LMA) Supreme (LMAS) versus the LMA Proseal (LMAP) in elective laparoscopic cholecystectomy. OBJECTIVES To compare the LMAS with LMAP in terms of ventilatory efficacy, airway leak pressure (airway protection), ease-of-use and complications. DESIGN Prospective, single-blind,(More)
In this paper we present efficient multigrid methods for systems of partial differential equations that are governed by a dominating grad-div operator. In particular, we show that distributive smoothing methods give multigrid convergence factors that are independent of problem parameters and of the mesh sizes in space and time. The applications range from(More)
This paper deals with the numerical approximation of the solution of 1D parabolic singularly perturbed problems of reaction–diffusion type. The numerical method combines the standard implicit Euler method on a uniform mesh to discretize in time and a HODIE compact fourth order finite difference scheme to discretize in space, which is defined on a priori(More)
In this paper a singularly perturbed reaction-diffusion partial differential equation in two space dimensions is examined. By means of an appropriate decomposition, we describe the asymptotic behaviour of the solution of problems of this kind. A central finite difference scheme is constructed for this problem which involves an appropriate Shishkin mesh. We(More)
A two-point boundary value problem is considered on the interval [0, 1], where the leading term in the differential operator is a Caputo fractional derivative of order δ with 1 < δ < 2. Writing u for the solution of the problem, it is known that typically u′′(x) blows up as x→ 0. A numerical example demonstrates the possibility of a further phenomenon that(More)
STUDY OBJECTIVE To evaluate the Laryngeal Mask Airway Supreme (SLMA) in patients undergoing laparoscopic cholecystectomy. DESIGN Prospective observational study. SETTING University-affiliated hospital. PATIENTS 100 ASA physical status 1, 2, and 3 adult patients undergoing laparoscopic cholecystectomy with general anesthesia. INTERVENTIONS The SLMA(More)
The tumour molecular profile predicts the activity of epidermal growth factor receptor (EGFR) inhibitors in non-small-cell lung cancer (NSCLC). However, tissue availability and tumour heterogeneity limit its assessment. We evaluated whether [18F]FDG PET might help predict KRAS and EFGR mutation status in NSCLC. Between January 2005 and October 2011, 340(More)