soluciones sostenibles para acabar con el hambre y la pobreza Apoyado por el CGIAR (IFPRI ®) was established in 1975 to provide sustainable solutions for ending hunger and poverty. IFPRI is one of 15 agricultural research centers that receives its principal funding from governments, private foundations, and international and regional organizations, most of… (More)
Abnormalities in monocytes and in peripheral blood dendritic cells (DC) subsets have been reported in systemic lupus erythematosus (SLE). We aim to clarify the tolerogenic or inflammatory role of these cells based on ICOSL or IFN-α and chemokine mRNA expression, respectively, after cell purification. The study included 18 SLE patients with active disease… (More)
An input-output model with non-constant returns to scale and externalities is presented, and it is shown that in this model, the non-substitution theorem is still valid. More precisely, the quantity side of the theorem, i.e., the proposition on efficiency, remains valid, while there can be no equilibrium prices independent of final demand.
Here, we evaluated the distribution and functional profile of circulating CD27+ and CD27− γδ T-cell subsets in systemic sclerosis (SSc) patients to assess their potential role in this disorder. Peripheral blood from 39 SSc patients and 20 healthy individuals was used in this study. The TCR-γδ repertoire, cytokine production and cytotoxic signatures of… (More)
Cost-effective intervention thresholds (ITs) based on FRAX® were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteoporotic fractures and hip above 8.8 and 2.5… (More)
A importância destas interacções era já forte-mente sugerida por observações clássicas, entre as quais destaco a descoberta dos potentes efeitos moduladores do cortisol (uma hormona) sobre o sistema imunológico, por Philip Hench e seus co-laboradores. 1 Stress e ansiedade são há muito re-conhecidos como factores de agravamento da diabetes 2,3 e o impacto… (More)