Jose R. Regueiro

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The biologic role of each CD3 chain and their relative contribution to the signals transduced through the TCR/CD3 complex and to downstream activation events are still controversial: they may be specialized or redundant. We have immortalized peripheral blood CD4+ and CD8+ T lymphocytes from a human selective CD3 gamma deficiency using Herpesvirus saimiri.(More)
CD3 proteins may have redundant as well as speci®c contributions to the intracellular propagation and ®nal effector responses of TCR-mediated signals at different checkpoints during T cell differentiation. We report here on the participation of CD3g in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.(More)
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