Jos R. C. Jansen

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OBJECTIVE To measure the relationship between blood flow and central venous pressure (Pcv) and to estimate mean systemic filling pressure (Pmsf), circulatory compliance, and stressed volume in patients in the intensive care unit. DESIGN Intervention study. SETTING Intensive care unit of a university hospital. PATIENTS Twelve mechanically ventilated(More)
Effects of changes in blood volume on changes in pulmonary blood flow and pulmonary blood volume during the ventilatory cycle during mechanical ventilation with a positive end-expiratory pressure of 2 cm H2O were determined in six pentobarbital anaesthetized, curarized pigs weighing about 10 kg. Haemodynamic variables were analysed for each cardiac cycle in(More)
To assess the level of agreement between different bedside estimates of effective circulating blood volume—mean systemic filling pressure (Pmsf), arm equilibrium pressure (Parm) and model analog (Pmsa)—in ICU patients. Eleven mechanically ventilated postoperative cardiac surgery patients were studied. Sequential measures were made in the supine position,(More)
BACKGROUND Mean systemic filling pressure (Pmsf) can be determined at the bedside by measuring central venous pressure (Pcv) and cardiac output (CO) during inspiratory hold maneuvers. Critical closing pressure (Pcc) can be determined using the same method measuring arterial pressure (Pa) and CO. If Pcc > Pmsf, there is then a vascular waterfall. In this(More)
Guyton's theory on venous return, implying a linear relationship between blood flow and central venous pressure, was tested in an intact circulation after thoracotomy and airtight chest closure. In eleven Yorkshire pigs (approx. 10 kg) we measured flow in the pulmonary artery and aorta and pressure in the central veins and aorta during pentobarbital(More)
OBJECTIVE The authors evaluated the ability of 2 pulse contour cardiac output (CO) techniques to track CO changes during passive leg raising (PLR) to assess fluid loading responsiveness. DESIGN A prospective study. SETTING An intensive care unit in a university hospital. PARTICIPANTS Twenty mechanically ventilated postoperative cardiac surgery(More)
BACKGROUND Mean systemic filling pressure (Pmsf) can be measured at the bedside with minimally invasive monitoring in ventilator-dependent patients using inspiratory hold maneuvers (Pmsf(hold)) as the zero flow intercept of cardiac output (CO) to central venous pressure (CVP) relation. We compared Pmsf(hold) with arm vascular equilibrium pressure during(More)
Many methods of cardiac output measurement have been developed, but the number of methods useful for human pharmacological studies is limited. The 'holy grail' for the measurement of cardiac output would be a method that is accurate, precise, operator independent, fast responding, non-invasive, continuous, easy to use, cheap and safe. This method does not(More)
Mean systemic filling pressure (P sf) is an indicator of the filling state of the systemic circulation. Cardiac output (Q′) is related linearly to the difference betweenP sf and central venous pressure (P cv), according to:Q′ = (P sf −P cv)/R sf, whereR sf is the flow resistance downstream from the sites where blood pressure is equal toP sf In 16(More)
BACKGROUND Mathematical coupling may explain in part why cardiac filling volumes obtained by transpulmonary thermodilution may better predict and monitor responses of cardiac output to fluid loading than pressures obtained by pulmonary artery catheters (PACs). METHODS Eleven consecutive patients with hypovolaemia after coronary surgery and a PAC, allowing(More)