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  • Alfred H. Schinkel, Jaap Jan J. Smit, Olaf van Tellingen, Jos H. Beijnen, Piet Borst
  • Medicine, Biology
  • Cell
  • 1994 (First Publication: 1 May 1994)
  • We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P-glycoprotein. The mice were viable and fertile and appeared phenotypicallyExpand
  • Johan W. Jonker, Marije Buitelaar, +9 authors Alfred H. Schinkel
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 12 November 2002)
  • The breast cancer resistance protein (BCRP/ABCG2) is a member of the ATP-binding cassette family of drug transporters and confers resistance to various anticancer drugs. We show here that miceExpand
  • Esther F. A. Brandon, Christiaan D Raap, Irma Meijerman, Jos H. Beijnen, Jan H M Schellens
  • Biology, Medicine
  • Toxicology and applied pharmacology
  • 2003 (First Publication: 1 June 2003)
  • The liver is the predominant organ in which biotransformation of foreign compounds takes place, although other organs may also be involved in drug biotransformation. Ideally, an in vitro model forExpand
  • Alex Sparreboom, Judith van Asperen, +7 authors Olaf van Tellingen
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1997 (First Publication: 4 March 1997)
  • In mice, the mdr1a and mdr1b genes encode drug-transporting proteins that can cause multidrug resistance in tumor cells by lowering intracellular drug levels. These P-glycoproteins are also found inExpand
  • M Maliepaard, Margôt A van Gastelen, +6 authors Jan H.M. Schellens
  • Biology, Medicine
  • Clinical cancer research : an official journal of…
  • 2001 (First Publication: 1 April 2001)
  • This study was aimed at characterizing the role of BCRP/MXR/ABCP (BCRP) in resistance of the human ovarian tumor cell lines T8 and MX3 to camptothecins more extensively and investigating whetherExpand
  • Jan Wijnholds, Raymond Evers, +7 authors Piet Borst
  • Medicine, Biology
  • Nature Medicine
  • 1997 (First Publication: 1 November 1997)
  • The multidrug resistance-associated protein (MRP) mediates the cellular excretion of many drugs, glutathione S-conjugates (GS-X) of lipophilic xenobiotics and endogenous cysteinyl leukotrienes1–5.Expand