Jos G. W. Kosterink

Klaus D. Wutzke2
Henderik W. Frijlink2
Herman J. Woerdenbag2
2Klaus D. Wutzke
2Henderik W. Frijlink
2Herman J. Woerdenbag
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Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity. This article provides an overview of all published pharmacokinetic studies on drug interactions of the commonly prescribed antimicrobial drugs(More)
PURPOSE The increasing incidence of small renal tumors in an aging population with comorbidities has stimulated the development of minimally invasive treatments. This study aimed to assess the efficacy and demonstrate feasibility of multimodality imaging of intratumoral administration of holmium-166 microspheres ((166)HoAcAcMS). This new technique locally(More)
INTRODUCTION Prescribing medication is an important aspect of almost all in-hospital treatment regimes. Besides their obviously beneficial effects, medicines can also cause adverse drug events (ADE), which increase morbidity, mortality and health care costs. Partially, these ADEs arise from medication errors, e.g. at the prescribing stage. ADEs caused by(More)
  • Marina J. M. Maurer, Reinout C. A. Schellekens, Klaus D. Wutzke, Gerard Dijkstra, Herman J. Woerdenbag, Henderik W. Frijlink +2 others
  • 2012
Conventional bioavailability testing of dosage forms based on plasma concentration-time graphs of two products in a two-period, crossover-design, is not applicable to topical treatment of intestinal segments. We introduce an isotope dual-label approach (13C- and 15N2-urea) for colon drug delivery systems that can be performed in a one-day, non-invasive(More)
BACKGROUND Drug-drug interactions (DDIs) are very prevalent in hospitalized patients. OBJECTIVES To determine the number of DDI alerts, time saved, and time invested after suppressing clinically irrelevant alerts and adding clinical-decision support to relevant alerts. MATERIALS AND METHODS The most frequently occurring DDIs were evaluated for clinical(More)
  • Jacoba M. Maurer, Reinout C. A. Schellekens, Hèlen M. van Rieke, Christoph Wanke, Ventzeslav Iordanov, Frans Stellaard +7 others
  • 2015
INTRODUCTION ColoPulse tablets are an innovative development in the field of oral dosage forms characterized by a distal ileum and colon-specific release. Previous studies in humans showed release in the ileo-colonic region, but the relationship between gastrointestinal pH and release was not experimentally proven in vivo. This information will complete the(More)
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