Federico V. Pallardó2
Consuelo Borrás2
2Federico V. Pallardó
2Consuelo Borrás
Learn More
  • Antonia Tomás-Loba, Ignacio Flores, Pablo J. Fernández-Marcos, María L. Cayuela, Antonio Maraver, Agueda Tejera +7 others
  • 2008
Telomerase confers limitless proliferative potential to most human cells through its ability to elongate telomeres, the natural ends of chromosomes, which otherwise would undergo progressive attrition and eventually compromise cell viability. However, the role of telomerase in organismal aging has remained unaddressed, in part because of the(More)
  • Consuelo Borrás, Daniel Monleón, Raul López-Grueso, Juan Gambini, Leonardo Orlando, Federico V. Pallardó +3 others
  • 2011
RasGRF1 is a Ras-guanine nucleotide exchange factor implicated in a variety of physiological processes including learning and memory and glucose homeostasis. To determine the role of RASGRF1 in aging, lifespan and metabolic parameters were analyzed in aged RasGrf1(-/-) mice. We observed that mice deficient for RasGrf1(-/-) display an increase in average and(More)
BACKGROUND Glutathione is considered essential for survival in mammalian cells and yeast but not in prokaryotic cells. The presence of a nuclear pool of glutathione has been demonstrated but its role in cellular proliferation and differentiation is still a matter of debate. PRINCIPAL FINDINGS We have studied proliferation of 3T3 fibroblasts for a period(More)
BACKGROUND Several studies suggest that pathological changes in Alzheimer's disease (AD) brain begin around 10-20 years before the onset of cognitive impairment. Biomarkers that can support early diagnosis and predict development of dementia would, therefore, be crucial for patient care and evaluation of drug efficacy. Although cerebrospinal fluid (CSF)(More)
Distributed SQL Query Engines (DSQEs) are increasingly used in variety of domains, but especially users in small companies with little expertise may face the challenge of selecting an appropriate engine for their specific applications. Although both industry and academia are attempting to come up with high level benchmarks, the performance of DSQEs has(More)
OBJECTIVE An evaluation is made of pain, swelling and peri-implant attached mucosal width after implant-based rehabilitation involving guided surgery and a modification of the technique with the raising of a semicircular miniflap, in single and partial replacements. STUDY DESIGN A case-control study was carried out. The study group consisted of 12(More)
  • 1