José T. Saavedra

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Enterococci are commensals of the gastrointestinal tracts (GITs) of animals, from simple invertebrates to humans, and likely evolved early in a primitive GIT-type environment [1–3]. This presumption is supported by their ubiquity and their streamlined genomes (an indicator of host adaptation, which results in a number of nutritional needs that must be(More)
We examined the evolutionary history of leading multidrug resistant hospital pathogens, the enterococci, to their origin hundreds of millions of years ago. Our goal was to understand why, among the vast diversity of gut flora, enterococci are so well adapted to the modern hospital environment. Molecular clock estimation, together with analysis of their(More)
Transposons can be used to easily generate and label the location of mutations throughout bacterial and other genomes. Transposon insertion mutants may be screened for a phenotype as individual isolates, or by selection applied to a pool of thousands of mutants. Identifying the location of a transposon insertion is critical for connecting phenotype to the(More)
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