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STUDY OBJECTIVES To determine predictors of neuropsychological functioning in patients with obstructive sleep apnea (OSA) and whether treatment with 2-week continuous positive airway pressure (CPAP) or supplemental oxygen would improve cognitive functioning. DESIGN Randomized placebo-controlled design. SETTING University-based clinical research center.(More)
STUDY OBJECTIVES Measurement of arousals from sleep is clinically important, however, their definition is not well standardized, and little data exist on reliability. The purpose of this study is to determine factors that affect arousal scoring reliability and night-to-night arousal variability. DESIGN The night-to-night arousal variability and(More)
STUDY OBJECTIVES We studied the effect of continuous positive airway pressure (CPAP) treatment on sympathetic nervous activity in 38 patients with obstructive sleep apnea. DESIGN Randomized, placebo-controlled trial. SETTING Patients underwent polysomnography on three occasions in a clinical research center, and had BP monitored over 24 h at home. All(More)
Obstructive sleep apnea (OSA) is associated with recurrent episodes of nocturnal hypoxia and increased risk for development of systemic hypertension. Prior studies have been limited, however, in their ability to show reduction in blood pressure after continuous positive airway pressure (CPAP) therapy, and the effect of supplemental oxygen alone on blood(More)
O bstructive sleep apnea (OSA) has serious cardiovas-cular consequences and increases the risk of stroke. OSA is common in patients with stroke 3,4 and is associated with impaired quality of life, reduced cognitive function, and excessive fatigue, 5–7 conditions that are common in stroke victims and that may delay poststroke recovery. It is possible that(More)
BACKGROUND AND OBJECTIVE Studies suggest that some acetylcholinesterase inhibitors (AChEIs) increase rapid eye movement (REM) sleep and nightmares in patients with Alzheimer's disease (AD) but few have studied their effect on other sleep parameters. The objective of this study was to examine differences in sleep architecture in AD patients taking different(More)
OBJECTIVES To assess the usefulness of actigraphy for assessment of nighttime sleep measures in patients with Parkinson's disease (PD). DESIGN Participants underwent overnight sleep assessment simultaneously by polysomnography (PSG) and actigraphy. SETTING Overnight sleep study in academic sleep research laboratory. PARTICIPANTS Sixty-one patients(More)
OBJECTIVE The aim of the current study was to investigate the frequency of periodic limb movements in sleep (PLMS) in Parkinson's disease (PD) and their impact on nocturnal sleep and daytime functioning. METHODS Forty-five PD patients (mean age 68.5 ± 8.7 years; 32 males) underwent one night of polysomnography (PSG). Clinical assessment and questionnaires(More)
OBJECTIVE Rapid eye movement (REM)-sleep behavior disorder (RBD) is often comorbid with Parkinson's disease (PD). The current study aimed to provide a detailed understanding of the impact of having RBD on multiple non-motor symptoms (NMS) in patients with PD. METHODS A total of 86 participants were evaluated for RBD and assessed for multiple NMS of PD.(More)
Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovas-cular responses in obstructive sleep apnea. (OSA) is characterized by noradrenergic activation. Nasal continuous positive airway pressure (CPAP) is the treatment of choice and has been shown to effectively reduce elevated norepinephrine(More)