José S Fortunato

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The inhibitory effect of 50 mg/kg lysyl acetylsalicylic acid (ASA) intravenously injected 24 and 4 h before 80 micrograms/kg adrenaline, 40 mg/kg indobufen injected 15 min before, or a combination of ASA plus indobufen on the platelet aggregation and kinetics was evaluated in anaesthetized dogs previously injected with 111indium- (111In-) labelled platelets(More)
The platelet (Plt) contribution to cardiovascular events triggered by adrenergic stress is supported by some experimental and necropsy data, but a cause and effect link and mechanism have not yet been clearly demonstrated. Adrenergic stress was simulated by three successive adrenaline (A) injections (80 micrograms/kg) in anesthetized dogs previously infused(More)
The belief that organs such as the heart could only undergo hypertrophy but not hyperplasia has been challenged with the discovery that differentiated cells can be constantly regenerated by stem cells (SCs). The dogma considering the heart as a post-mitotic organ has been questioned by the demonstration of continuous renewal of cardiomyocytes produced by(More)
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