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BACKGROUND AND PURPOSE Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder caused by mutations in the CYP27A1 gene resulting in sterol-27-hydroxylase deficiency. Current information about CTX is based mainly on case reports, with only few large series reported. Although perceived as a potentially treatable condition, efficacy of(More)
Canopy transpiration (E c) of a 50-year-old Pinus canariensis Chr. Sm. Ex DC. stand at tree line in Tenerife, Canary Islands, was estimated continuously throughout a year from March 1, 2008, to February 28, 2009, by means of xylem sap flow measurements. E c varied markedly throughout the entire year generally following the seasonal trends in soil water(More)
BACKGROUND The low probability of curing high-risk prostate cancer (PC) with local therapy suggests the need to study modality of therapeutic approaches. To this end, a prospective phase II trial of neoadjuvant docetaxel (D) and complete androgen blockade (CAB) was carried out in high-risk PC patients. The primary end point was to detect at least 10% of(More)
We are reporting a case of neurobrucellosis that was clinically and radiologically indistinguishable from a cerebral tumor. The histological diagnosis was granulomatous encephalitis. The diagnosis was established by enzyme-linked immunosorbent assay (ELISA), detecting high levels of Ig G and Ig M Brucella antibodies in the serum and the cerebrospinal fluid.(More)
We analyzed the seasonal patterns of sap flow density (Q s) and stem radius variation (SRV) of Spartocytisus supranubius, a dominant, endemic tree-like shrub of the mountain vegetation at high elevation in Tenerife, Canary Islands. We tested the hypotheses that drought and its effect on water status and on radial growth (RG) is primarily related to(More)
OBJECTIVE To analyse the profile of medical prescription and prescription habits in the most common illnesses in a Primary Health Care district. DESIGN Descriptive crossover study. SETTING Algeciras-La Línea (Cádiz) Primary Care district. MEASUREMENTS AND MAIN RESULTS A randomised sample of clinical histories stratified by months was selected. This(More)
BACKGROUND Gait disorder is very prevalent in multiple sclerosis. After 15 years of disease progression, 50% of patients need assistive devices for walking. MATERIALS & METHODS We performed a multicenter observational study, including multiple sclerosis patients with an Expanded Disability Status Scale score between 4.0 and 7.0, normal kidney function and(More)
Tree growth of Pinus canariensis at treeline in Tenerife, Canary Islands, is thought to be primarily controlled by wet season precipitation (P) prior to the current year´s growth. Therefore, we investigated the inter-annual variations in stem water deficit (ΔW) and radial growth (RG) during two consecutive years differing in wet season P. ΔW was extracted(More)
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