José R. Santos

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The Interdisciplinary Telecommunications Program at the University of Colorado has developed an internet based remote laboratory environment for master's level graduate students; our suite of telecommunications experiments substantially extends prior work focused on networking equipment, by (1) providing a systems focus, (2) enabling multiple reinforcing(More)
1 This paper presents a new architecture for Optical Burst Switched networks featuring a novel common control channel (C 3-OBS). The control plane of the network is shared and distributed, enabling better network resource planning at each node. A model of the C 3-OBS OXC Node is proposed, the manageable bandwidth of a C 3-OBS network is assessed and the(More)
BACKGROUND Data on suppression of HIV replication in the CNS and on the subsequent risk of neurocognitive impairment using monotherapy with boosted protease inhibitors are limited. METHODS Ours was an exploratory cross-sectional study in patients on lopinavir/ritonavir-based monotherapy (LPV/r-MT) or standard triple therapy (LPV/r-ART) for at least 96(More)
The new architectural approach to Optical Burst Switching networks presented here features a common control channel and a node locally maintained network model. The Common Control Channel allows for a fast and efficient broadcast of the network Control Packets, which in turn are used by every node to update its Local Network Model. The Local Network Model(More)
BACKGROUND Simplification of antiretroviral treatment (ART) with darunavir/ritonavir (DRV/r) monotherapy has achieved sustained suppression of plasma viral load (pVL) in clinical trials; however, its effectiveness and safety profile has not been evaluated in routine clinical practice. METHODOLOGY/PRINCIPAL FINDINGS We performed a retrospective cohort(More)
BACKGROUND The current economic recession in European countries has forced governments to design emergency measures to reduce spending on drugs, including antiretroviral therapy (ART). Switching antiretroviral drugs for others that have the same efficacy and safety profile at a lower cost (cost-reduction measures, CRM) could prove to be a valid means of(More)
OBJECTIVES The aim of this study was to characterize the prevalence and patterns of genotypic integrase inhibitor (INI) resistance in relation to HIV-1 clade. METHODS The cohort comprised 533 INI-naive subjects and 255 raltegravir recipients with viraemia who underwent integrase sequencing in routine care across Europe, including 134/533 (25.1%) and(More)
BACKGROUND Switching subjects with persistently undetectable HIV-1 viremia under antiretroviral treatment (ART) to once-daily tenofovir/emtricitabine (or lamivudine) + nevirapine is a cost-effective and well-tolerated strategy. However, the effectiveness of this approach has not been established. METHODS We performed a retrospective study evaluating the(More)
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