José R. Santos

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The Interdisciplinary Telecommunications Program at the University of Colorado has developed an internet based remote laboratory environment for master's level graduate students; our suite of telecommunications experiments substantially extends prior work focused on networking equipment, by (1) providing a systems focus, (2) enabling multiple reinforcing(More)
BACKGROUND Although antiretroviral therapy improves immune response, some human immunodeficiency virus-infected patients present unsatisfactory CD4 T cell recovery despite achieving viral suppression, resulting in increased morbidity and mortality. METHODS Cross-sectional, case-control study to characterize the mechanism and to identify predictive factors(More)
BACKGROUND Data on suppression of HIV replication in the CNS and on the subsequent risk of neurocognitive impairment using monotherapy with boosted protease inhibitors are limited. METHODS Ours was an exploratory cross-sectional study in patients on lopinavir/ritonavir-based monotherapy (LPV/r-MT) or standard triple therapy (LPV/r-ART) for at least 96(More)
1 This paper presents a new architecture for Optical Burst Switched networks featuring a novel common control channel (C 3-OBS). The control plane of the network is shared and distributed, enabling better network resource planning at each node. A model of the C 3-OBS OXC Node is proposed, the manageable bandwidth of a C 3-OBS network is assessed and the(More)
The new architectural approach to Optical Burst Switching networks presented here features a common control channel and a node locally maintained network model. The Common Control Channel allows for a fast and efficient broadcast of the network Control Packets, which in turn are used by every node to update its Local Network Model. The Local Network Model(More)
BACKGROUND Simplification of antiretroviral treatment (ART) with darunavir/ritonavir (DRV/r) monotherapy has achieved sustained suppression of plasma viral load (pVL) in clinical trials; however, its effectiveness and safety profile has not been evaluated in routine clinical practice. METHODOLOGY/PRINCIPAL FINDINGS We performed a retrospective cohort(More)
BACKGROUND The clinical relevance of ultrasensitive human immunodeficiency virus type 1 (HIV-1) genotypic resistance testing in antiretroviral treatment (ART)-experienced individuals remains unknown. METHODS This was a retrospective, multicentre, cohort study in ART-experienced, HIV-1-infected adults who initiated salvage ART including, at least 1(More)
BACKGROUND The current economic recession in European countries has forced governments to design emergency measures to reduce spending on drugs, including antiretroviral therapy (ART). Switching antiretroviral drugs for others that have the same efficacy and safety profile at a lower cost (cost-reduction measures, CRM) could prove to be a valid means of(More)
OBJECTIVES The aim of this study was to develop and validate a population pharmacokinetic model for nevirapine in a population of HIV-infected adults and to evaluate the influence of nevirapine dosing regimen and patient characteristics on nevirapine trough concentration. METHODS HIV-infected adults receiving oral nevirapine for at least 4 weeks were(More)
BACKGROUND It is unknown if tenofovir disoproxil fumarate (TDF), which is often coformulated with the lipid-neutral emtricitabine (FTC), has a lipid-lowering effect. METHODS We performed a randomized, crossover, double-blind, placebo-controlled clinical trial on human immunodeficiency virus type 1 (HIV-1)-infected subjects with HIV-1 RNA < 50 copies/mL(More)