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The influence of basic open-loop synaptic connections on the firing of simultaneously recorded neurons has been investigated with auto- and cross-correlation histograms, using experimental records and computer simulations. The basic connections examined were direct synaptic excitation, direct synaptic inhibition, and shared synaptic input. Each type of(More)
The consequences of inhibitory or excitatory synaptic input between pacemaker neurons were predicted mathematically and through digital-computer simulations, and the predicted behavior was found to occur in abdominal ganglia of Aplysia and in stretch receptors of Procambarus. Discharge patterns under conditions that do not involve interneuronal feedback are(More)
This paper studies the influence exerted by the presynaptic spike train on the postsynaptic one. It applies to synaptic exploration a novel method for characterization of point-process systems (Brillinger, 1974, 1975a), and draws from it physiologically meaningful conclusions. The departure point was a large data set of action potential trains from an(More)
1. Those features of a transmembrane current correlated with spike initiation were examined in Aplysia neurones using a Gaussian white-noise stimulus. This stimulus has the advantages that it presents numerous wave forms in random order without prejudgement as to their efficacies, and that it allows straightforward statistical calculations. 2. Stimulation(More)
A complete description of the sequence of spikes in a neuron discharge consists of an ordered series of intervals t lt t 2 , ..., t n , extending over the entire observation time. Neurophysiologists commonly discuss ongoing activity in terms of mean frequency of spikes thus ignoring variability and sequence of intervals. Histograms of intervals between two(More)
An elementary model of neuronal activity involves temporal and spatial summation of postsynaptic currents that are elicited by presynaptic spikes and that, in turn, elicit postsynaptic potentials at a trigger zone; when the potential at the trigger zone exceeds a "threshold" level, a postsynaptic spike is generated. This paper describes three methods of(More)