José Miguel Carot

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BACKGROUND Polymorphic variations in the serotonin transporter gene (5-HTT) moderate the depressogenic effects of tryptophan depletion. After childbirth there is a sharp reduction in brain tryptophan availability, thus polymorphic variations in 5-HTT may play a similar role in the post-partum period. AIMS To study the role of 5-HTT polymorphic variations(More)
OBJECTIVES To classify the tumor areas in patients with grade IV astrocytoma by calculating and statistically analyzing quantitative MRI perfusion parameters. MATERIAL AND METHODS We applied two models of MRI perfusion, the unicompartmental and the pharmacokinetic models, in 15 patients diagnosed with grade IV astrocytoma. In the unicompartmental model,(More)
Physiological changes during gestation and after delivery are associated with postpartum thyroid dysfunction, which is due to thyroid autoimmunity in some cases. Postpartum thyroid dysfunction, in turn, has been associated with postpartum depression (PPD). The aim of the present study was to evaluate whether thyroid function immediately after delivery can(More)
In Alzheimer's disease (AD) brains increased NO synthase (NOS) expression is found in reactive astrocytes surrounding amyloid plaques. We have recently shown that treatment with beta-amyloid peptides or IL-1beta down-regulates NO-sensitive soluble guanylyl cyclase (sGC) in cultured astrocytes and in adult rat brain. In this work, we have examined sGC(More)
The aim of this work was the development of multivariate models able to determine the content of the main crocetin esters and picrocrocin from spectrophotometric data that could be used for routine quality control of saffron. These compounds were determined with HPLC in Spanish saffron, and their absorbance spectra from 190 to 700 nm were simultaneously(More)
This is the first study to be carried out on the incidence of halophenols and haloanisoles, including trichloroanisole, in aged red wines. A total of 966 red wines, aged for 6, 12 and 24 months in oak barrels and from different Spanish production areas, were analysed by stir bar sorptive extraction followed by gas chromatography/mass spectrometry (GC/MS).(More)
OBJECTIVE The aims of this study were to review studies on the molecular genetics of child temperament and prospectively analyze infant temperament as a function of the interaction between infant and mother: 5-HTT, DRD4, and MAO-A functional polymorphisms and the mother's emotional state. METHOD A prospective study of 317 newborns and their mothers was(More)
Normal and degenerated cartilages have different magnetic resonance (MR) capillary permeability (Ktrans) and interstitial interchangeable volume (ve). Our hypothesis was that glucosamine sulfate treatment modifies these neovascularity abnormalities in osteoarthritis. Sixteen patients with patella degeneration, randomly distributed into glucosamine or(More)
BACKGROUND Volatile fraction profile and physicochemical parameters were studied with the aim of evaluating their effectiveness for the differentiation between lemon blossom honey (Citrus limon L.) and orange blossom honey (Citrus spp.). They would be useful complementary tools to the traditional analysis based on the percentage of pollen. RESULTS A(More)
Better understanding of child temperament is essential, as it may predict subsequent development of psychopathology. Questionnaires which have been adapted to Spanish population include a rather restricted age range. The Emotionality Sociability and Activity (EAS) Temperament Survey has been widely used in child temperament genetic research. A Spanish(More)