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BACKGROUND The exposure of phosphatidylserine occurs during platelet (PLT) activation and during in vitro storage. Phosphatidylserine exposure also occurs during apoptosis after the release of mitochondrial cytochrome c. We have examined the role of cytochrome c release, mitochondrial membrane potential (ΔΨm), and cyclophilin D (CypD) in phosphatidylserine(More)
Cystic fibrosis (CF) is characterized by a massive proinflammatory phenotype in the lung, caused by mutations in the CFTR gene. IL-8 and other proinflammatory mediators are elevated in the CF airway, and the immediate mechanism may depend on disease-specific stabilization of IL-8 mRNA in CF lung epithelial cells. MAPK signaling pathways impact directly on(More)
For Cys-loop ligand-gated ion channels (LGIC), the protein movements that couple neurotransmitter binding to channel gating are not well known. The pre-M1 region, which links the extracellular agonist-binding domain to the channel-containing transmembrane domain, is in an ideal position to transduce binding site movements to gating movements. A cluster of(More)
TRPV2 is a member of the transient receptor potential family of ion channels involved in chemical and thermal pain transduction. Unlike the related TRPV1 channel, TRPV2 does not appear to bind either calmodulin or ATP in its N-terminal ankyrin repeat domain. In addition, it does not contain a calmodulin-binding site in the distal C-terminal region, as has(More)
␥-Aminobutyric acid (GABA) binding to GABA A receptors (GABA A Rs) triggers conformational movements in the ␣ 1 and ␤ 2 pre-M1 regions that are associated with channel gat-ing. At high concentrations, the barbiturate pentobarbital opens GABA A R channels with similar conductances as GABA, suggesting that their open state structures are alike. Little,(More)
Gamma-aminobutyric acid (GABA) binding to GABA(A) receptors (GABA(A)Rs) triggers conformational movements in the alpha(1) and beta(2) pre-M1 regions that are associated with channel gating. At high concentrations, the barbiturate pentobarbital opens GABA(A)R channels with similar conductances as GABA, suggesting that their open state structures are alike.(More)
The Editors would like to thank the following reviewers for their assistance: Chedly Abdelly Suzanne Abrams David Alabadi Marino Arnao Tadao Asami Carol Auer Belay Ayele C. Bailly Frantisek Baluska Juan Barcelo Lenore Barkan Stefan Bartram Richard Beckett Gerard Bishop Fitzgerald Booker Gerd Bossinger Rubén Bottini Margaret Boulton Melissa Brechner Adina(More)
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