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Connexin43 (Cx43) is a gap junction protein that forms multimeric channels that enable intercellular communication through the direct transfer of signals and metabolites. Although most multimeric protein complexes form in the endoplasmic reticulum (ER), Cx43 seems to exit from the ER as monomers and subsequently oligomerizes in the Golgi complex. This(More)
In contrast to most multimeric transmembrane complexes that oligomerize in the endoplasmic reticulum (ER), the gap junction protein connexin43 (Cx43) oligomerizes in an aspect of the Golgi apparatus. The mechanisms that prevent oligomerization of Cx43 and related connexins in the ER are not well understood. Also, some studies suggest that connexins can(More)
We examine the absolute luminosities of 29 SNe Ia in the Calán/Tololo survey. We confirm a relation between the peak luminosity of the SNe and the decline rate as measured by the light curve, as suggested by Phillips (1993). We derive linear slopes to this magnitude-decline rate relation in BV(I)KC colors, using a sample with BMAX-VMAX < 0.2. The scatter(More)
The High-Z Supernova Search is an international collaboration to discover and monitor type Ia supernovae (SN Ia) at z > 0.2 with the aim of measuring cosmic deceleration and global curvature. Our collaboration has pursued a basic understanding of supernovae in the nearby Universe, discovering and observing a large sample of objects, and developing methods(More)
We develop a method for estimating the host galaxy dust extinction for type Ia supernovae based on an observational coincidence first noted by Lira (1995), who found that the B − V evolution during the period from 30–90 days after V maximum is remarkably similar for all events, regardless of light curve shape. This fact is used to calibrate the dependence(More)
We present extensive optical and infrared photometry of the afterglow of gamma-ray burst (GRB) 030329 and its associated supernova (SN) 2003dh over the first two months after detection (2003 March 30-May 29 UT). Optical spectroscopy from a variety of telescopes is shown and, when combined with the photometry, allows an unambiguous separation between the(More)
We report the discovery of a new double-image gravitational lens resulting from our search for lenses in the southern sky. Radio source PMN J2004–1349 is composed of two compact components separated by 1. 13 in VLA, MERLIN and VLBA images. The components have a flux ratio of 1:1 at radio frequencies ranging from 5 GHz to 22 GHz. The I-band optical(More)
To examine early events in connexin oligomerization, we made connexin constructs containing a C-terminal di-lysine based endoplasmic reticulum (ER) retention/retrieval signal (HKKSL). Previously, we found that both Cx32-HKKSL and Cx43-HKKSL were retained in the ER. However, Cx32-HKKSL oligomerized into hexameric hemichannels, but Cx43-HKKSL was retained as(More)
Stars that explode as supernovae come in two main classes. A type Ia supernova is recognized by the absence of hydrogen and the presence of elements such as silicon and sulphur in its spectrum; this class of supernova is thought to produce the majority of iron-peak elements in the Universe. They are also used as precise 'standard candles' to measure the(More)
The Calán/Tololo supernova survey has discovered ∼30 Type Ia supernovae at redshifts out to z∼0.1. Using BV(I)KC data for these objects and nearby SNe Ia, we have shown that there exists a significant dispersion in the intrinsic luminosities of these objects. We have devised a robust χminimization technique simultaneously fitting the BVI light curves to(More)