José María Gutiérrez

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Mobile learning is considered an evolution of e-learning that embraces the ubiquitous nature of current computational systems in order to improve teaching and learning. Within this context it is possible to develop mobile applications oriented to learning, but it is also important to assess to what extent such applications actually work. In this paper we(More)
E nvenoming resulting from snake bites is an important public health hazard in many regions, particularly in tropical and subtropical countries [1–3]. Although antivenoms are being produced by various laboratories in every continent, the burden of snake bite envenoming— causing both morbidity and mortality—still has a great impact on the population and on(More)
A learning object can be considered as a unit of instructional content for which a metadata record describing its characteristics and intended educational usage is provided. Metadata records can be used to develop effective search and location of learning objects, and also to develop automated or semi-automated selection and composition tools. In(More)
— In this paper we propose a system that allows to adapt educational contents to learners, based on the knowledge of a learner who is conducting the training through his mobile device, contents will also be tailored to the features of the device and to the context where the learner is at the present moment.
Standards and specifications widely accepted and used lay the foundations to enable and facilitate the interoperability among systems, and the software maintenance and reuse, especially within the scope of learning objects' search systems. One of these standards is the SQI (Standard Query Interface) specification by the European Committee for(More)
Protein-protein interfaces have crucial functions in many biological processes. The large interaction areas of such interfaces show complex interaction motifs. Even more challenging is the understanding of (multi)specificity in protein-protein binding. Many proteins can bind several partners to mediate their function. A perfect paradigm to study such(More)
The direct estimate of 46,000 snakebite deaths in India in 2005 (1 for every 2 HIV/AIDS deaths), based on verbal autopsies, renders unrealistic the total of only 47,000 snakebite deaths in the whole world in 2010, obtained indirectly as part of the "Global Burden of Disease 2010" study. Persistent underestimation of its true morbidity and mortality has made(More)
Hemorrhage is a clinically important manifestation of viperid snakebite envenomings, and is induced by snake venom metalloproteinases (SVMPs). Hemorrhagic and non-hemorrhagic SVMPs hydrolyze some basement membrane (BM) and associated extracellular matrix (ECM) proteins. Nevertheless, only hemorrhagic SVMPs are able to disrupt microvessels; the mechanisms(More)
The learning objects paradigm actually drives the majority of researches and commercial developments in e-learning field. Nevertheless, this paradigm has been harshly criticized due to the fact that it has not achieved the objectives proposed in its initial definition. This, together with some false assumptions surrounding the e-learning concept, have led(More)
Current e-learning applications should provide universal access to educational information, regardless of the standards, protocols or programming languages used. This would maximize the reuse of learning objects and help this technology to gain its place as a fundamental and, in some cases only, support tool for present day educational systems. To achieve(More)