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INTRODUCTION The Symbol Digit Modalities Test (SDMT) is a widely used test for the evaluation of neurological disorders. Normative data have been published for this test in different populations, however there are no values regarding elderly persons residing in geriatric homes. This study has aimed to apply the SDMT on a sample made up of Spanish elderly(More)
Many hormones and neurotransmitters evoke Ca2+ release from intracellular stores, often triggering agonist-specific signatures of intracellular Ca2+ concentration. Inositol trisphosphate (InsP3) and cyclic adenosine 5'-diphosphate-ribose (cADPR) are established Ca2+-mobilizing messengers that activate Ca2+ release through intracellular InsP3 and ryanodine(More)
Agonist-evoked cytosolic Ca(2+) spikes in mouse pancreatic acinar cells are specifically initiated in the apical secretory pole and are mostly confined to this region. The role played by mitochondria in this process has been investigated. Using the mitochondria-specific fluorescent dyes MitoTracker Green and Rhodamine 123, these organelles appeared as a(More)
Hormones and neurotransmitters mobilize Ca(2+) from the endoplasmic reticulum via inositol trisphosphate (IP(3)) receptors, but how a single target cell encodes different extracellular signals to generate specific cytosolic Ca(2+) responses is unknown. In pancreatic acinar cells, acetylcholine evokes local Ca(2+) spiking in the apical granular pole, whereas(More)
The benefits of physical exercise to reduce low-grade inflammation and improve Brain-Derived Neurotrophic Factor (BDNF) levels and cognitive function became a growing field of interest. Low-grade inflammation is common during aging and seems to be linked to neurodegenerative process. Regular physical exercises can help to reduce pro-inflammatory cytokines(More)
In order to control cell functions, hormones and neurotransmitters generate an amazing diversity of Ca2+ signals such as local and global Ca2+ elevations and also Ca2+ oscillations. In pancreatic acinar cells, cholecystokinin (CCK) stimulates secretion of digestive enzyme and promotes cell growth, whereas acetylcholine (ACh) essentially triggers enzyme(More)
In the nervous system, Ca2+ signalling is determined primarily by voltage-gated Ca2+-selective channels in the plasma membrane, but there is increasing evidence for involvement of intracellular Ca2+ stores in such signalling. It is generally assumed that neurotransmitter-elicited release of Ca2+ from internal stores is primarily mediated by Ins(1,4,5)P3, as(More)
OBJECTIVE To compare the effects of 2 different water-based exercise training programs on functional mobility, motor symptoms, and quality of life (QOL) on patients with mild to moderate Parkinson's disease (PD). DESIGN Matched, controlled, pilot study. SETTING Outpatient Parkinson's disease center. PARTICIPANTS Patients (N=21) with PD (Hoehn and Yahr(More)
The aim of this study is to identify personal factors associated with drugs use and the practice of physical activity in a college student population in northwest Spain. A cross-sectional survey was conducted between January and April 2010 using a self-administered questionnaire including questions concerning gender, age, course and year of study, living(More)
OBJECTIVE This pilot study aimed to determine if the Senior Fitness Test (SFT) battery can be applied to subjects with Parkinson's disease (PD) and whether its results can be reliable indicators of disease severity. METHODS Thirty people with mild to moderate PD performed the SFT and completed the Parkinson's Disease Questionnaire (PDQ-39) and the Unified(More)