José Manuel García Verdugo

Learn More
After trauma brain injury, a large number of cells die, releasing neurotoxic chemicals into the extracellular medium, decreasing cellular glutathione levels and increasing reactive oxygen species that affect cell survival and provoke an enlargement of the initial lesion. Alpha-lipoic acid is a potent antioxidant commonly used as a treatment of many(More)
We describe a new molecular mechanism of cell death by excitotoxicity mediated through nuclear transcription factor kappa B (NF kappa B) in rat embryonic cultures of dopaminergic neurons. Treatment of mesencephalic cultures with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) resulted in a number of changes that occurred selectively in(More)
According to ultrastructure, size and location within the dorsal cortex of Lacerta galloti, six basic types of neuronal somata are described in this study. In the outer plexiform layer only few neuronal somata with nuclear invaginations can be detected (type A). In the granular stratum, large neuronal somata (type B) receiving axo-somatic synapses and(More)
The ventral septum of the reptile Podarcis hispánica has been studied using cytoarchitectonical and Golgi methods as well as electron microscopy techniques. The ventral septum is located in the medial wall of the telencephalon, just ventral to the dorsal septum. 2 different cell masses or nuclei can be easily appreciated in this structure: the(More)
In this work an ultrastructural analysis of the nuclear inclusions of neurons of chick (Gallus gallus) dorsomedial cerebral cortex during different perinatal stages has been made. Two types of nuclear inclusions could be identified: a) membranous nuclear inclusions and b) nuclear bodies. Into the type of membranous nuclear inclusions we distinguish compact(More)
According to ultrastructure, size, and location within the medial cortex of Lacerta galloti, seven basic kinds of neuronal somata are described in this study. In the outer plexiform layer of the medial cortex only a few somata can be detected. There, moreover some oligodendroglia and microglia cells a few neuronal somata showing conspicuous nuclear(More)
According to ultrastructure, size, and location within the lateral region of the cerebral cortex of Lacerta galloti, four basic types of neuronal somata are described: a) large neuronal somata of the granular stratum, b) neuronal somata having large nuclear invaginations, c) medium size somata of the granular layer with abundant lipofuscine granules, and d)(More)
We aimed to identify new cell-membrane antigens implicated in opsoclonus-myoclonus with neuroblastoma. The sera of 3 out of 14 patients showed IgG electron-microscopy immunogold reactivity on SH-SY5Y neuroblastoma cells. Immunoprecipitation experiments using rat brain synaptosomes and SH-SY5Y cells led to the identification of: (1) thirty-one(More)
  • 1