José Manuel Fonseca

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BACKGROUND Drusen are common features in the ageing macula associated with exudative Age-Related Macular Degeneration (ARMD). They are visible in retinal images and their quantitative analysis is important in the follow up of the ARMD. However, their evaluation is fastidious and difficult to reproduce when performed manually. METHODS This article proposes(More)
Agents that buy and sell goods or services in an electronic market need to adapt to the environment's prevailing conditions if they are to be successful. Here we propose an on-line, continuous learning mechanism that is especially adapted for agents to learn how to behave when negotiating for resources (goods or services). Taking advantage of the specific(More)
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MOTIVATION Cell division in Escherichia coli is morphologically symmetric. However, as unwanted protein aggregates are segregated to the cell poles and, after divisions, accumulate at older poles, generate asymmetries in sister cells' vitality. Novel single-molecule detection techniques allow observing aging-related processes in vivo, over multiple(More)
Managing resources in the framework of the civil construction sector is usually an extremely complex task. The great number as well as the variety of existing resources, both human and material, the diversity of tasks each working unity is able to execute, the degree of quality of its performance, the involved costs, the spatial distribution of all(More)
Negotiation is a kind of decision making where two or more parties jointly search a space of solutions with the goal of reaching a consensus. This search usually is a single dimension process where the different agents, involved in the negotiation process, mutually adapt their price offers in order to reach their goals (to sell or to buy a good). However,(More)
Missing values are common in medical datasets and may be amenable to data imputation when modelling a given data set or validating on an external cohort. This paper discusses model averaging over samples of the imputed distribution and extends this approach to generic non-linear modelling with the Partial Logistic Artificial Neural Network (PLANN)(More)
Prognostic modelling involves grouping patients by risk of adverse outcome, typically by stratifying a severity of illness index obtained from a classifier or survival model. The assignment of thresholds on the risk index depends of pairwise statistical significance tests, notably the log-rank test. This paper proposes a new methodology to substantially(More)
The traditional methodology used in civil engineering measurements requires a lot of equipment and a very complex procedure especially if the number of target points increase. Since the beginning of the current century, several studies have been conducted in the area of photogrametry using digital image correlation associated with block motion algorithms to(More)