José M. González

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A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human(More)
As orchestrators of essential cellular processes like proliferation, ERK1/2 mitogen-activated protein kinase signals impact on cell cycle regulation. A-type lamins are major constituents of the nuclear matrix that also control the cell cycle machinery by largely unknown mechanisms. In this paper, we disclose a functional liaison between ERK1/2 and lamin A(More)
BACKGROUND Chromosomal Comparative Genomic Hybridization (CGH) has been applied to all stages of cervical carcinoma progression, defining a specific pattern of chromosomal imbalances in this tumor. However, given its limited spatial resolution, chromosomal CGH has offered only general information regarding the possible genetic targets of DNA copy number(More)
Sequestration of c-Fos at the nuclear envelope (NE) through interaction with A-type lamins suppresses AP-1-dependent transcription. We show here that c-Fos accumulation within the extraction-resistant nuclear fraction (ERNF) and its interaction with lamin A are reduced and enhanced by gain-of and loss-of ERK1/2 activity, respectively. Moreover, hindering(More)
The sophistication and complexity of analysis performed by today's network intrusion prevention systems (IPSs) benefits greatly from implementation using general-purpose CPUs. Yet the performance of such CPUs increasingly lags behind that necessary to process today's high-rate traffic streams. A key observation, however, is that much of the traffic(More)
Stateful, in-depth, inline traffic analysis for intrusion detection and prevention is growing increasingly more difficult as the data rates of modern networks rise. Yet it remains the case that in many environments, much of the traffic comprising a high-volume stream can, after some initial analysis, be qualified as of "likely uninteresting." We present a(More)
The structure of many standalone network intrusion detection systems (NIDSs) centers around a chain of analysis that begins with packets captured by a packet filter, where the filter describes the protocols (TCP/UDP port numbers) and sometimes hosts or subnets to include or exclude from the analysis. In this work we argue for augmenting such analysis with(More)
BACKGROUND Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development. METHODS An immunohistochemical study was performed using tissue arrays and specific(More)
OBJECTIVE The tumor suppressor p53 regulates cell proliferation and apoptosis, two key processes in the pathogenesis of occlusive vascular disease. Here, we examined the consequences of heightening p53 function on neointimal lesion formation in the setting of atherosclerosis and mechanical injury. METHODS For this study we employed immunohistopathological(More)