José M. González

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A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein complexes that regulate nuclear structure and functions. Interest in these proteins has increased in recent years with the discovery that LMNA mutations cause a variety of human(More)
BACKGROUND Poxviruses evade the immune system of the host through the action of viral encoded inhibitors that block various signalling pathways. The exact number of viral inhibitors is not yet known. Several members of the vaccinia virus A46 and N1 families, with a Bcl-2-like structure, are involved in the regulation of the host innate immune response where(More)
As orchestrators of essential cellular processes like proliferation, ERK1/2 mitogen-activated protein kinase signals impact on cell cycle regulation. A-type lamins are major constituents of the nuclear matrix that also control the cell cycle machinery by largely unknown mechanisms. In this paper, we disclose a functional liaison between ERK1/2 and lamin A(More)
The difficulty associated with the cultivation of most microorganisms and the complexity of natural microbial assemblages, such as marine plankton or human microbiome, hinder genome reconstruction of representative taxa using cultivation or metagenomic approaches. Here we used an alternative, single cell sequencing approach to obtain high-quality genome(More)
The sophistication and complexity of analysis performed by today's network intrusion prevention systems (IPSs) benefits greatly from implementation using general-purpose CPUs. Yet the performance of such CPUs increasingly lags behind that necessary to process today's high-rate traffic streams. A key observation, however, is that much of the traffic(More)
Stateful, in-depth, inline traffic analysis for intrusion detection and prevention is growing increasingly more difficult as the data rates of modern networks rise. Yet it remains the case that in many environments, much of the traffic comprising a high-volume stream can, after some initial analysis, be qualified as of "likely uninteresting." We present a(More)
The structure of many standalone network intrusion detection systems (NIDSs) centers around a chain of analysis that begins with packets captured by a packet filter, where the filter describes the protocols (TCP/UDP port numbers) and sometimes hosts or subnets to include or exclude from the analysis. In this work we argue for augmenting such analysis with(More)
Proteorhodopsins are globally abundant photoproteins found in bacteria in the photic zone of the ocean. Although their function as proton pumps with energy-yielding potential has been demonstrated, the ecological role of proteorhodopsins remains largely unexplored. Here, we report the presence and function of proteorhodopsin in a member of the widespread(More)
  • Olof P Persson, Jarone Pinhassi, Lasse Riemann, Britt-Inger Marklund, Mikael Rhen, Staffan Normark +2 others
  • 2009
Marine bacteria can cause harm to single-celled and multicellular eukaryotes. However, relatively little is known about the underlying genetic basis for marine bacterial interactions with higher organisms. We examined whole-genome sequences from a large number of marine bacteria for the prevalence of homologues to virulence genes and pathogenicity islands(More)
Three Gram-negative, rod-shaped, aerobic bacteria that were capable of degrading dimethylsulfoniopropionate (DMSP) were isolated from marine waters. These isolates (DSS-3(T), DSS-10 and ISM(T)) exhibited the ability to demethylate and cleave DMSP, as well as to degrade other sulfur compounds related to DMSP that are cycled in marine environments.(More)