José M. Ferrero

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Several mathematical models of rabbit ventricular action potential (AP) have been proposed to investigate mechanisms of arrhythmias and excitation-contraction coupling. Our study aims at systematically characterizing how ionic current properties modulate the main cellular biomarkers of arrhythmic risk using two widely-used rabbit ventricular models, and(More)
In this study, we have used computer simulations to study the mechanisms of extracellular K+ accumulation during acute ischemia. A modified version of the Luo-Rudy phase II action potential model was used to simulate the electrical behavior of one ventricular myocyte during 14 min of simulated ischemia. Our results show the following: 1) only the integrated(More)
The goal of this modeling research is to provide mechanistic insight into the effect of altered membrane kinetics associated with 5-12 min of acute global ischemia on the upper limit of cardiac vulnerability (ULV) to electric shocks. We simulate electrical activity in a finite-element bidomain model of a 4-mm-thick slice through the canine ventricles that(More)
Accurate diagnosis of long QT syndrome is a key factor for reducing the risk of cardiac arrhythmias. Our goal is to investigate the potential use of dofetilide to unmask latent I<sub>Kr</sub> mutation carriers. A modified version of the O'Hara et al. model was used to simulate the electrical activity of isolated cardiac cells. The original I<sub>Kr</sub>(More)
In this work, we have studied the vulnerable window and propagation patterns in a human heart during acute ischemia. A 3-D biventricular model of a human heart with realistic heterogeneity and fiber orientations has been considered. The ischemic region was located in the anterior left ventricular wall mimicking the occlusion of the circumflex artery. The(More)
The aim of this work was to study the influence of pore KCNH2 mutation on the effects of dofetilide. Markovian models of G604S/WT mutation and dofetilide have been introduced in guinea pig ventricular cellular model. The effects of this pore mutation affecting this channel were analyzed. The G604S/WT mutation accelerates the inactivation and recovery from(More)
Under pathological conditions, such as LQT3, drugs that selectively block late Na<sup>+</sup> current (I<sub>NaL</sub>) exert antiarrhythmic effects by reducing action potential duration (APD). Some of these compounds also block the delayed rectifier K<sup>+</sup> current (I<sub>Kr</sub>) exerting an opposite effect. This study was designed to determine the(More)
Bundle branch reentry (BBR) is a complex triggering mechanism of ventricular tachycardia, which initiation and maintenance are not well understood. We present a multi-scale functional model of the His bundle and bundle branches coupled to a simplified representation of the septum to study initiation and maintenance of BBR in-silico. The model includes a(More)
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