José M. Ferrero

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Several mathematical models of rabbit ventricular action potential (AP) have been proposed to investigate mechanisms of arrhythmias and excitation-contraction coupling. Our study aims at systematically characterizing how ionic current properties modulate the main cellular biomarkers of arrhythmic risk using two widely-used rabbit ventricular models, and(More)
In this study, we have used computer simulations to study the mechanisms of extracellular K+ accumulation during acute ischemia. A modified version of the Luo-Rudy phase II action potential model was used to simulate the electrical behavior of one ventricular myocyte during 14 min of simulated ischemia. Our results show the following: 1) only the integrated(More)
The goal of this modeling research is to provide mechanistic insight into the effect of altered membrane kinetics associated with 5-12 min of acute global ischemia on the upper limit of cardiac vulnerability (ULV) to electric shocks. We simulate electrical activity in a finite-element bidomain model of a 4-mm-thick slice through the canine ventricles that(More)
Action potential (AP) changes occurring in ischemic myocytes predispose the myocardium to fibrillation and sudden death. Ischemia is a critical and unstable condition, so experiments are difficult to conduct at the cellular level in human. The aim of this work is to use computational models to investigate the dynamic changes in human ischemic myocardium at(More)
Multi-electrode array systems are increasingly being used to study atrial electrical excitation in humans and are shedding new light on the mechanisms of atrial fibrillation (AF). However the mapping systems that are currently being used to characterize the rotors that are postulated to drive AF have not been systematically analyzed for accuracy. Computer(More)
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