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We describe a procedure, RNAPol-ChIP, to measure actual transcriptional rate. It consists of the detection, by chromatin immunoprecipitation (ChIP), of RNA polymerase II within the coding region of genes. To do this, the DNA immunoprecipitated with polymerase antibodies is analysed by PCR, using an amplicon well within the coding region of the desired genes(More)
Conventional treatment of non-small cell lung cancer (NSCLC) has apparently reached a plateau of effectiveness in improving the survival of the patients. For that reason the search for new therapeutic strategies in this type of tumor is justified. 1E10 is an anti-idiotype murine monoclonal antibody (Ab2 MAb) specific to P3 Ab1 MAb, which reacts with(More)
PURPOSE This study evaluated changes in weight, glucose and lipid metabolism in patients with schizophrenia and antipsychotic-related metabolic disturbances who were switched to ziprasidone. METHODS Eighty-four outpatients with schizophrenia or schizoaffective disorder also having glucose intolerance, diabetes, dyslipidemia or weight gain related to their(More)
Trees necessarily experience changes in temperature, requiring efficient short-term strategies that become crucial in environmental change adaptability. DNA methylation and histone posttranslational modifications have been shown to play a key role in both epigenetic control and plant functional status under stress by controlling the functional state of(More)
In order to enable tight interaction and close collaboration between human and service robots it is necessary that robots imitate the cognitive mechanisms of the brain and their role in competent activity control. That goal can only be achieved if robots are capable of observing their environment, reasoning about it, and autonomously deciding the most(More)
Mitogen-activated protein kinases (MAPKs) are considered major signal transducers early during the development of acute pancreatitis. Pentoxifylline is a phosphodiesterase inhibitor with marked anti-inflammatory properties through blockade of extracellular signal regulated kinase (ERK) phosphorylation and tumor necrosis factor alpha production. Our aim was(More)
Investigación – forma de citar/how to cite – informe revisores/referees – agenda – metadatos – PDF – Creative Commons Palabras clave: televisión; información política; debate electoral. Abstract: The Academy of Television was the allegedly neutral scenario for the organization of the debate between the PSOE and the PP of the Spanish general elections of(More)
Mycobacterium tuberculosis infections are uncommon complications in the haematopoietic stem cell post-transplant period. Most cases are reactivations of latent infections affecting the lung. We present an atypical case of isolated lymph node tuberculosis after an allogeneic haematopoietic stem cell transplantation, which highlights the importance of having(More)
Adventitious organogenesis from zygotic embryos is one of the most reliable techniques to propagate clonal Pinus radiata individuals. Regulation of gene expression has an important role to generate a correct caulogenic pattern, and genomic DNA methylation is amongst the main studied regulatory mechanisms in animals and plants. The aim of this work is to(More)
Neurosurgery has been refined to an armless and frameless neuronavigational system in recent years. In the past 50 years we have seen a significant advancement in this field from its humble birth to today's CT, MRI and computer application. Stereotactic (from the Greek stereo, three dimensions; tactic, to probe) is a term to describe procedures done in a(More)