José Luis López Sendón

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The importance of resting heart rate (HR) as a prognostic factor and potential therapeutic target is not yet generally accepted. Recent large epidemiologic studies have confirmed earlier studies that showed resting HR to be an independent predictor of cardiovascular and all-cause mortality in men and women with and without diagnosed cardiovascular disease.(More)
Huntington's disease (HD) is a neurodegenerative disorder characterized by progressive motor, cognitive and psychiatric deficits, associated with predominant loss of striatal neurons and is caused by polyglutamine expansion in the huntingtin protein. Mutant huntingtin protein and its fragments are resistant to protein degradation and produce a blockade of(More)
INTRODUCTION AND OBJECTIVES We present the results from the PREVESE Study, conducted in two phases: the first to identify the secondary prevention measurements recommended in Spain in patients who were discharged after a myocardial infarction; the second, 6 months later, to determine their evolution. METHODS Data was collected from 1,242 patients in 39(More)
In patients with systemic hypertension there is progressive left ventricular remodelling characterized mainly by left ventricular hypertrophy accompanied by abnormal diastolic ventricular function. Regional ischaemia, secondary to abnormal myocardial perfusion may explain in part the decrease in relaxation and compliance of the hypertrophied left ventricle.(More)
BACKGROUND We sought to examine the impact of gender on the investigation and subsequent management of stable angina and to assess gender differences in clinical outcome at 1 year. METHODS AND RESULTS The Euro Heart Survey of Stable Angina enrolled patients with a clinical diagnosis of stable angina on initial assessment by a cardiologist. Baseline(More)
Mortality and morbidity in acute coronary syndromes (ACSs), caused principally by plaque erosion or rupture leading to thrombus formation and myocardial ischemia, have been reduced by a combination of antithrombotic agents (antiplatelet drugs and anticoagulants) and early revascularization. Aspirin is the foundation antiplatelet agent. New P2Y12 receptor(More)
AIMS Among acute coronary syndromes (ACS), ST-segment elevation myocardial infarction (STEMI) has the most severe early clinical course. We aimed to describe the effectiveness and safety of P2Y12 receptor inhibitors in patients with STEMI based on the data from contemporary European ACS registries. METHODS AND RESULTS Twelve registries provided data in a(More)
Pulmonary artery dissection is a rare clinical entity, which has been related to pulmonary arterial hypertension. It is frequently presented as cardiogenic shock or sudden death, so diagnosis is often made at autopsy. The management with best results is surgery. We report a case of pulmonary artery dissection associated with previous aortic valve(More)
A propuesta del comité de guías clínicas de la SEC, las Secciones de Hipertensión y Prevención Cardiovascular y Rehabilitación Cardiaca seleccionaron un grupo de cardiólogos expertos en PCV para revisar las Guías de PCV publicadas este año por la ESC y traducidas en REVISTA ESPAÑOLA DE CARDIOLOGÍA. El objetivo es comentar la naturaleza y la oportunidad de(More)