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TOR (target of rapamycin) is a phosphatidylinositol kinase-related protein kinase that controls cell growth in response to nutrients. Rapamycin is an immunosuppressive and anticancer drug that acts by inhibiting TOR. The modes of action of TOR and rapamycin are remarkably conserved from S. cerevisiae to humans. The current understanding of TOR and rapamycin(More)
Reversible protein phosphorylation plays an important role in many cellular processes. However, a simple and reliable method to measure changes in the extent of phosphorylation is lacking. Here, we present a method to quantitate the changes in phosphorylation occurring in a protein in response to a stimulus. The method consists of three steps: (i) enzymatic(More)
This paper is concerned with different aspects of the use of evolution for the successful generation of real robot ANN controllers. Several parameters of an evolutionary/genetic algorithm and the way they influence the evolution of ANN behavioral controllers for real robots have been contemplated. These parameters include the way the initial populations are(More)
Target of rapamycin (TOR) kinases control cell growth through two functionally distinct multiprotein complexes. TOR complex 1 (TORC1) controls temporal cell growth and is sensitive to rapamycin, whereas TOR complex 2 (TORC2) is rapamycin resistant and regulates spatial cell growth. Here, we identified two TOR orthologues, TbTOR1 and TbTOR2, in the protozoan(More)
We discuss here empirical comparation between model selection methods based on Linear Genetic Programming. Two statistical methods are compared: model selection based on Empirical Risk Minimization (ERM) and model selection based on Structural Risk Minimization (SRM). For this purpose we have identified the main components which determine the capacity of(More)
BACKGROUND In the last 20 years, Cetacean Morbillivirus (CeMV) has been responsible for many die-offs in marine mammals worldwide, as clearly exemplified by the two dolphin morbillivirus (DMV) epizootics of 1990-1992 and 2006-2008, which affected Mediterranean striped dolphins (Stenella coeruleoalba). Between March and April 2011, the number of strandings(More)
Hydrogen sulfide is already recognized as an important signaling molecule in mammalian systems, and emerging data suggest that H2S is a signaling molecule just as important as nitric oxide (NO) and H2O2 in plants. Although sulfide is generated in chloroplasts and mitochondria, it is present predominantly in the charged HS (-) form due to the basic pH inside(More)
– The application of Gaussian Synapse based Artificial Neural Networks to the detection and unmixing of endmembers within hyperspectral images is the objective of this paper, especially in cases where some of them are mixed in a low ratio as is usually the case in target detection problems. These networks and the training algorithm developed are very(More)