Learn More
The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors(More)
Gliosarcomas are rare and poorly characterized malignant brain tumors that exhibit a biphasic tissue pattern with areas of gliomatous and sarcomatous differentiation. These tumors are histological variants of glioblastoma, displaying a similar genetic profile and dismal prognosis. Up-regulation of PDGFR subfamily of tyrosine kinase members, PDGFR-α and(More)
This paper describes the development of a robust speech recognition using a database collected in the scope of the Tecnovoz project. The speech recognition system is speaker independent, robust to noise and operates in a small footprint embedded hardware platform. Some issues about the database, the training of the acoustic models, the noise suppression(More)
The conserved serine/threonine kinase mTOR (the mammalian target of rapamycin), a downstream effector of the PI3K/AKT pathway, forms two distinct multiprotein complexes: mTORC1 and mTORC2. mTORC1 is sensitive to rapamycin, activates S6K1 and 4EBP1, which are involved in mRNA translation. It is activated by diverse stimuli, such as growth factors, nutrients,(More)
This paper describes the early stages of porting REAP, a tutoring system for vocabulary learning, to European Portuguese. Students learn from authentic materials, on topics of their preference. A large number of linguistic resources and filtering tools have already been integrated into the ported version. We modified the current system to also target oral(More)
BACKGROUND Malignant gliomas are the most prevalent type of primary brain tumours but the therapeutic armamentarium for these tumours is limited. Platelet-derived growth factor (PDGF) signalling has been shown to be a key regulator of glioma development. Clinical trials evaluating the efficacy of anti-PDGFRA therapies on gliomas are ongoing. In this study,(More)
Angiogenesis is an essential step for breast cancer progression and dissemination. The development of new blood vessels in cancer setting (angiogenesis) is conducted by numerous physiological and pathological stimuli, where the main stimulus is hypoxia. The knowledge of different molecular pathways regulating angiogenesis is constantly growing. An increased(More)
—When humans and computers use the same terms (primes, when they entrain to one another), spoken dialogs proceed more smoothly. The goal of this paper is to describe initial steps we have found that will enable us to eventually automatically choose better primes in spoken dialog system prompts. Two different sets of prompts were used to understand what(More)
Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was(More)