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BACKGROUND Previous animal studies have demonstrated that the transmural extent of acute myocardial infarction defined by contrast-enhanced MRI (ceMRI) relates to early restoration of flow and future improvements in contractile function. We tested the hypothesis that ceMRI would have similar predictive value in humans. METHODS AND RESULTS Twenty-four(More)
BACKGROUND A technical advance in contrast-enhanced magnetic resonance imaging (MRI) has significantly improved image quality. We investigated whether healed myocardial infarction can be visualised as hyperenhanced regions with this new technique, and whether assessment of the transmural extent of infarction yields new physiological data. METHODS 82 MRI(More)
The aim of this study was to describe the postweaning growth of Iberian piglets and its relationship with the occurrence of diarrhea. To assess these factors in response to different weaning ages, a total of 360 pure-breed Iberian piglets were studied. Three trials were conducted with 120 piglets from 24 litters randomly assigned to be weaned at 28 or 42 d(More)
OBJECTIVES This study examines whether the coronary artery calcium (CAC) score can be used to define the target population to treat with a polypill. BACKGROUND Prior studies have suggested a single polypill to reduce cardiovascular disease (CVD) at the population level. METHODS Participants from MESA (Multi-Ethnic Study of Atherosclerosis) were(More)
OBJECTIVE The benefits of fish oil fatty acids eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) on plasma lipid profiles have been inconsistent but may partially depend on individual Apolipoprotein E (APOE) genotypes. We aimed to determine whether APOE genotype modifies the association of lipid profile characteristics with plasma EPA and DHA levels.(More)
Coronary computed tomographic angiography (CCTA) is emerging as a key non-invasive method for assessing cardiovascular risk by measurement of coronary stenosis and coronary artery calcium (CAC). New advancements in CCTA technology have led to the ability to directly identify and quantify the so-called "vulnerable" plaques that have features of positive(More)
—In this paper, a new approach for the statistical characterization of a measurand is presented. A description of how different bootstrap techniques can be applied in practice to estimate successfully a measurand probability density function (pdf) is given. When the direct observation of a quantity of interest is practically impossible such as in(More)
In this paper we propose to continue in the same research line initiated by Pronzato and Thierry (Pronzato et al, 2000a), (Pronzato et al, 2000b), (Pronzato et al, 2001), recent works inspired in the minimum-entropy estimation have been published by De la Rosa and Fleury (De la Rosa et al, 2002), (De la Rosa et al, 2003) in the instrumentation framework. An(More)